Integration of High Field NMR into the Chemistry Curriculum

为了丰富当前的本科科学教育，NMR将被整合到整个化学课程中，以吸引化学、生物学、神经科学等专业的学生。学生将透过对分子结构的研究，体验科学探究的发现。核磁共振的广泛使用将在有机化学序列的早期开始，并将继续通过高年级学生/教师的研究。大部分实验室实验改编自J. Chem。建造。（JCE）文章或NSF-DUE赞助的工作。在有机化学中，分子对称和碳取代将通过Reeves-JCE'98报道的13c NMR和DEPT实验提前介绍。立体异构体和19f NMR将根据Branz-JCE'85, Piers-JCE'89和rojas - du -9952633的联合工作进行探索。同核和异核相关以及NOESY光谱将用于质子和碳的分配。这些二维实验将为实验室中的光谱分配提供确凿的证据，这些实验室因缺乏学生分析而受到影响，参见Piers-JCE'91；Mills-JCE 96;Castro-JCE 98;麦克唐纳，DUE- 9850423。仪器方法课程将探讨磁化率和各向异性，见Arnold-JCE'98。根据Brown-JCE'98和Dwyer-JCE'98的规定，物理化学实验室将实施基于构象异构体的动力学和热力学测定的变温核磁共振研究。Mathcad练习也将被用来帮助学生理解傅里叶变换过程是如何工作的。生物化学和高级有机课程将进一步利用二维技术，加上31p核磁共振，来分析gramicidin S和磷酸腺苷，参见Lee-JCE'96和craick - jce '91。学生/教师的研究项目也将受益于现代高场核磁共振。新仪器将包括梯度功能，以大幅减少采集时间和更高的磁场强度磁铁，以提高分辨率。宽带探针对于一些学生/教师的研究项目是必不可少的。该仪器和修订后的课程将有助于教育学生，激发他们对现代核磁共振光谱学的力量，并为他们在化学科学领域的职业生涯做好准备。

Chemistry (12) To enrich the current undergraduate science education, NMR will be integrated throughout the chemistry curriculum to engage students majoring in chemistry, biology, neuroscience, and other fields. Students will experience the discovery of scientific inquiry through investigation of molecular structure. Extensive use of NMR will begin early in the organic chemistry sequence and will continue through senior student/faculty research. Most of the laboratory experiments are adapted from J. Chem. Educ. (JCE) articles or NSF-DUE sponsored work. In organic chemistry molecular symmetry and carbon substitution will be introduced early via 13 C NMR and DEPT experiments as reported by Reeves-JCE'98. Stereoisomers and 19 F NMR will be explored according to the combined work of Branz-JCE'85, Piers-JCE'89, and Rojas-DUE-9952633. Homonuclear and heteronuclear correlation, as well as NOESY, spectra will be used to make proton and carbon assignments. These two dimensional experiments will provide hard evidence for spectral assignments in labs, which have suffered from lack of student analysis, see Piers-JCE'91; Mills-JCE'96; Castro-JCE'98; and McDonald, DUE- 9850423. The instrumental methods course will explore magnetic susceptibility and anisotropy, see Arnold-JCE'98. Physical chemistry labs will implement variable temperature NMR studies for kinetics and thermodynamic determinations based on conformational isomers according to Brown-JCE'98 and Dwyer-JCE'98. Mathcad exercises will also be employed to help students understand how the Fourier transform process works. Senior courses in biochemistry and advanced organic will further utilize 2D techniques, plus 31 P NMR, for analysis of gramicidin S and adenosine phosphates, see Lee-JCE'96 and Craik-JCE'91. Student/faculty research projects will likewise benefit from a modern high field NMR. The new instrument will include gradient capabilities to drastically reduce acquisition times and a higher field strength magnet to improve resolution. A broadband probe is essential for several student/faculty research projects. This instrument and the revised curriculum will together help to educate students, excite them about the power of modern NMR spectroscopy, and prepare them for careers in the chemical sciences.