Integration of High Field NMR into the Chemistry Curriculum

将高场核磁共振融入化学课程

• 批准号: 0088227
• 负责人: Ernest Nolen
• 金额: $ 18.68万
• 依托单位: Colgate University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0088227&HistoricalAwards=false
• 关键词: Integration; Field; NMR; into; Chemistry

Chemistry (12) To enrich the current undergraduate science education, NMR will be integrated throughout the chemistry curriculum to engage students majoring in chemistry, biology, neuroscience, and other fields. Students will experience the discovery of scientific inquiry through investigation of molecular structure. Extensive use of NMR will begin early in the organic chemistry sequence and will continue through senior student/faculty research. Most of the laboratory experiments are adapted from J. Chem. Educ. (JCE) articles or NSF-DUE sponsored work. In organic chemistry molecular symmetry and carbon substitution will be introduced early via 13 C NMR and DEPT experiments as reported by Reeves-JCE'98. Stereoisomers and 19 F NMR will be explored according to the combined work of Branz-JCE'85, Piers-JCE'89, and Rojas-DUE-9952633. Homonuclear and heteronuclear correlation, as well as NOESY, spectra will be used to make proton and carbon assignments. These two dimensional experiments will provide hard evidence for spectral assignments in labs, which have suffered from lack of student analysis, see Piers-JCE'91; Mills-JCE'96; Castro-JCE'98; and McDonald, DUE- 9850423. The instrumental methods course will explore magnetic susceptibility and anisotropy, see Arnold-JCE'98. Physical chemistry labs will implement variable temperature NMR studies for kinetics and thermodynamic determinations based on conformational isomers according to Brown-JCE'98 and Dwyer-JCE'98. Mathcad exercises will also be employed to help students understand how the Fourier transform process works. Senior courses in biochemistry and advanced organic will further utilize 2D techniques, plus 31 P NMR, for analysis of gramicidin S and adenosine phosphates, see Lee-JCE'96 and Craik-JCE'91. Student/faculty research projects will likewise benefit from a modern high field NMR. The new instrument will include gradient capabilities to drastically reduce acquisition times and a higher field strength magnet to improve resolution. A broadband probe is essential for several student/faculty research projects. This instrument and the revised curriculum will together help to educate students, excite them about the power of modern NMR spectroscopy, and prepare them for careers in the chemical sciences.

化学（12）为了丰富目前的本科科学教育，NMR将融入整个化学课程，以吸引化学，生物学，神经科学和其他领域的学生。学生将通过分子结构的调查体验科学探究的发现。核磁共振的广泛使用将开始在有机化学序列的早期，并将继续通过高级学生/教师的研究。大多数实验室实验改编自J. Chem. Educ.（JCE）文章或NSF-DUE赞助的工作。在有机化学中，分子对称性和碳取代将通过13 C NMR和DEPT实验早期引入，如Reeves-JCE'98所报道的。立体异构体和19 F NMR将根据Branz-JCE'85、Piers-JCE'89和Rojas-DUE-9952633的组合工作进行探索。将使用同源和异源相关以及NOESY光谱进行质子和碳分配。这些二维实验将为实验室中的光谱分配提供确凿的证据，这些实验室由于缺乏学生分析而遭受损失，参见Piers-JCE'91; Mills-JCE'96; Castro-JCE'98;和McDonald，DUE- 9850423。仪器方法课程将探讨磁化率和各向异性，见Arnold-JCE'98。物理化学实验室将根据Brown-JCE'98和Dwyer-JCE'98实施基于构象异构体的动力学和热力学测定的变温NMR研究。Mathcad练习也将被用来帮助学生理解傅里叶变换过程是如何工作的。生物化学和高级有机的高级课程将进一步利用2D技术，加上31 P NMR，用于短杆菌肽S和腺苷磷酸的分析，见Lee-JCE'96和Craik-JCE'91。学生/教师的研究项目也将受益于现代高场NMR。新仪器将包括梯度功能，以大大减少采集时间和更高的磁场强度磁铁，以提高分辨率。宽带探测器对于几个学生/教师研究项目是必不可少的。该仪器和修订后的课程将共同帮助教育学生，激发他们对现代NMR光谱的力量，并为他们在化学科学的职业生涯做好准备。