Integration of High Field NMR into the Chemistry Curriculum

化学(12)为了丰富当前的本科科学教育，核磁共振将被整合到整个化学课程中，让化学、生物、神经科学和其他领域的学生参与进来。学生将通过对分子结构的研究来体验科学探究的发现。核磁共振的广泛应用将在有机化学序列的早期开始，并将持续到高年级学生/教师的研究。大多数实验室实验都是从J.Chem改编的。电学。(JCE)应由NSF赞助的文章或作品。在有机化学中，分子对称性和碳取代将通过13CNMR和DEPT实验被较早地引入，如Reves-JCE‘98所报道的那样。立体异构体和19F核磁共振将根据Branz-JCE‘85、PIERS-JCE’89和Rojas-Due-9952633的联合工作进行探索。同核和异核关联以及NOESY光谱将被用于质子和碳的指认。这些二维实验将为实验室中的光谱分配提供确凿的证据，这些实验室一直缺乏学生分析，参见PIERS-JCE‘91；Mills-JCE’96；Castro-JCE‘98；和McDonald，DUE-9850423。仪器方法课程将探索磁化率和各向异性，参见Arnold-JCE‘98。物理化学实验室将根据Brown-JCE‘98和Dwyer-JCE’98对构象异构体进行动力学和热力学测定的变温核磁共振研究。还将使用Mathcad练习来帮助学生了解傅里叶变换过程的工作原理。生物化学和高级有机的高级课程将进一步利用2D技术和31P核磁共振技术来分析革兰菌素S和腺苷磷酸，见Lee-JCE‘96和Craik-JCE’91。学生/教师的研究项目同样将受益于现代高场核磁共振。新仪器将包括梯度功能，以大幅减少采集时间，以及更高的磁场强度，以提高分辨率。宽带探头对于几个学生/教师的研究项目是必不可少的。该仪器和修订后的课程将共同帮助教育学生，激发他们对现代核磁共振光谱学的力量的兴趣，并为他们在化学科学领域的职业生涯做好准备。

Chemistry (12) To enrich the current undergraduate science education, NMR will be integrated throughout the chemistry curriculum to engage students majoring in chemistry, biology, neuroscience, and other fields. Students will experience the discovery of scientific inquiry through investigation of molecular structure. Extensive use of NMR will begin early in the organic chemistry sequence and will continue through senior student/faculty research. Most of the laboratory experiments are adapted from J. Chem. Educ. (JCE) articles or NSF-DUE sponsored work. In organic chemistry molecular symmetry and carbon substitution will be introduced early via 13 C NMR and DEPT experiments as reported by Reeves-JCE'98. Stereoisomers and 19 F NMR will be explored according to the combined work of Branz-JCE'85, Piers-JCE'89, and Rojas-DUE-9952633. Homonuclear and heteronuclear correlation, as well as NOESY, spectra will be used to make proton and carbon assignments. These two dimensional experiments will provide hard evidence for spectral assignments in labs, which have suffered from lack of student analysis, see Piers-JCE'91; Mills-JCE'96; Castro-JCE'98; and McDonald, DUE- 9850423. The instrumental methods course will explore magnetic susceptibility and anisotropy, see Arnold-JCE'98. Physical chemistry labs will implement variable temperature NMR studies for kinetics and thermodynamic determinations based on conformational isomers according to Brown-JCE'98 and Dwyer-JCE'98. Mathcad exercises will also be employed to help students understand how the Fourier transform process works. Senior courses in biochemistry and advanced organic will further utilize 2D techniques, plus 31 P NMR, for analysis of gramicidin S and adenosine phosphates, see Lee-JCE'96 and Craik-JCE'91. Student/faculty research projects will likewise benefit from a modern high field NMR. The new instrument will include gradient capabilities to drastically reduce acquisition times and a higher field strength magnet to improve resolution. A broadband probe is essential for several student/faculty research projects. This instrument and the revised curriculum will together help to educate students, excite them about the power of modern NMR spectroscopy, and prepare them for careers in the chemical sciences.