U.S.-Japan Joint Seminar: Protein Folding, Function and Funnels

0089797 Luthey-Schulten该奖项支持美国科学家参与美国科学家协会的一项研究。2002年1月13日至19日在夏威夷檀香山举行的日本蛋白质折叠、功能和漏斗研讨会。 共同组织者是伊利诺伊大学厄巴纳-香槟分校的彼得·沃林斯教授和鲁塞-舒尔滕教授以及日本京都大学的高田翔二教授。 蛋白质折叠是一个非常重要的课题。 近年来，蛋白质折叠已经开始被视为在统计力学为基础的背景下，能量景观理论。 这一理论提供了一个框架，在其中可以分析蛋白质折叠的复杂动力学的定量处理。 该理论从随机聚合物系统的统计力学处理开始，并通过将蛋白质在折叠的各个阶段的集合的特征与可折叠蛋白质的能量景观的特征和性质联系起来来进行。 蛋白质折叠的能量景观方法的一个主要实际结果是从序列预测蛋白质结构的算法的成功取得了重大进展，这是后基因组生物学范式的重要组成部分。 它们的功能也很重要，特别是在基因调控领域。 与日本专家在这一领域的想法和数据交流将使美国参与者能够推进自己的工作，并为未来的合作项目奠定基础。 将在万维网上传播关于讨论会的资料。

0089797Luthey-SchultenThis award supports the participation of American scientists in a U.S.-Japan seminar on protein folding, function and funnels, to be held in Honolulu, Hawaii from January 13-19, 2002. The co-organizers are professors Peter Wolynes and Luthey-Schulten of the University of Illinois at Urbana-Champaign and Professor Shoji Takada at Kyoto University in Japan. The topic of protein folding is extremely important. In recent years, protein folding has begun to be viewed in the context of a statistical mechanics-based, energy landscape theory. This theory provides a framework in which quantitative treatment of complex dynamics of protein folding can be analyzed. The theory starts with the statistical mechanical treatment of random polymer systems and proceeds by linking characteristic features of ensembles of proteins at various stages of folding to features and properties of the energy landscape of foldable proteins. A major practical result of the energy landscape approach to protein folding has been a major advance in the success of algorithms for the prediction of protein structure from sequence, an important part of the post genomic paradigm of biology. They are also important in their function, especially in the area of gene regulation. The exchange of ideas and data with Japanese experts in this field will enable U.S. participants to advance their own work, and will set the stage for future collaborative projects. Dissemination of information on the seminar will be available on the World Wide Web.