Travel Award for Workshop "Towards in Silico Biological Cells: Bridging Experiments and Simulations" Lausanne, Switzerland

2012年7月9日至12日在瑞士洛桑举行的题为“迈向硅生物细胞：桥接实验和模拟”的研讨会将汇集来自两种基本和互补方法的研究人员，以模拟细菌细胞细胞质内的细胞过程动力学：基于粒子的布朗动力学算法，用于描述拥挤环境中的扩散传输；以及反应-扩散主方程，用于描述基因表达、遗传开关和在模拟生物细胞中发挥作用的生化路径的随机动力学。这次研讨会将提供机会，让来自分子模拟和系统生物学科学领域的研究人员与标记和成像细胞组件的实验者汇聚一堂。我们预计，这种交叉受精将导致在整个细胞、其组成部分、细胞分裂的计算建模以及普遍的转录和翻译过程与细胞代谢网络反应的耦合方面取得重大科学进展。

The July 9-12, 2012 workshop "Towards in silico biological cells: Bridging experiments and simulations" in Lausanne, Switzerland will bring together researchers from two basic and complementary approaches for simulating the dynamics of cellular processes within the cytoplasm of bacterial cells: particle-based Brownian dynamics algorithms that have been used to describe the diffusive transport in crowded environments and reaction-diffusion master equations that have been used to describe stochastic kinetics of gene expression, genetic switches and biochemical pathways functioning in modeled biological cells. This Workshop will provide the opportunity to bring researchers from the scientific fields of molecular simulations and system biology together with experimentalists who are labeling and imaging cellular components. We envision that this cross fertilization will lead to significant scientific advances in the computational modeling of an entire cell, its components, cell division and the coupling of universal processes of transcription and translation to the response of the cell's metabolic network.