CAREER: Bioinorganic Chemistry of Nitrogen/Sulfur Ligands Possessing Internal Hydrogen Bond Donors

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Dr. Lisa Berreau, Department of Chemistry, Utah State University, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry program, Division of Chemistry, National Science Foundation, through a Career Award for her work in which a new class of chelating nitrogen/sulfur ligands containing hydrogen bond donors will be developed. Complexes with zinc hydroxide, alkoxide and bicarbonate stabilized by internal hydrogen-bonds will be synthesized and characterized to determine structure/function relationships for several metalloenzymes toward design of new catalysts for the oxidation of alcohols, hydration of carbon dioxide, and hydrolytic cleavage of amides. In the educational front, a new bioinorganic chemistry course utilizing cooperative learning techniques, and two new undergraduate laboratory courses also incorporating bioinorganic chemistry elements will be developed.Students will receive a broad-based training in inorganic chemistry with significant insights into the chemistry of biological systems. The catalysts that will be developed are of technological importance.