Synthetic and Mechanistic Investigations of CO-releasing Divalent Metal Acireductone and Flavonolate Complexes

无机，生物无机和有机金属化学项目支持犹他州立大学（USU）的Lisa M. Berreau教授制备和表征二价金属乙酰化酮和黄酮酸盐配合物。一氧化碳（CO）最近被认为与平滑肌松弛有关，并可能参与触发（或抑制）细胞凋亡。co释放的机制途径，发生在处理这些配合物与氧被阐明。对CO的调控和产生的理解可能有助于深入了解金属稳态与生物学中其他调控机制之间的联系。本文研究了多齿吡啶基配体螯合的Ni(II) - C1(H)取代酸还原酮配合物的结构、稳定性和反应活性，并阐明了单电子转移和自由基化学在金属配位酸还原酮氧化中的作用。对金属离子同一性在指导乙酰化酮氧化的区域化学中的作用的理解也在发展中。参与研究的有研究生、本科生和高中生。USU ACS学生附属小组的活动使学生能够与当地的小学，初中和高中学生接触。Berreau教授和她的团队准备了动手色谱实验，这些实验可供犹他州洛根市的中学科学教师使用。每年夏天，当地一所特许高中的两名学生都会在实验室接受接待。

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports Professor Lisa M. Berreau of Utah State University (USU) for the preparation and characterization of divalent metal acireductone and flavonolate complexes. Carbon monoxide (CO) has recently been implied in smooth muscle relaxation and may be involved in triggering (or inhibiting) apoptosis. The mechanistic pathways of the CO-release that occur upon treatment of these complexes with oxygen are elucidated. The understanding of CO regulation and production may give insight into links between metal homeostasis and other regulatory mechanisms in biology. This work investigates the structure, stability and reactivity of C1(H)-substituted acireductone complexes with Ni(II) chelated by multidentate pyridine-based ligands and clarifies the role of single electron transfer and radical chemistry in the oxidation of a metal-coordinated acireductone. An understanding of the role of the metal ion identity in directing the regiochemistry of the acireductone oxidation is also being developed.Graduate, undergraduate and high school students participate in the research. The activities of the ACS Student Affiliate Group at USU bring students in contact with the elementary, middle and high school students in the local area. Professor Berreau and her group prepare hands-on chromatography experiments that are made available to middle school science teachers in Logan, Utah. Two students from a local charter high school are hosted in the laboratory each summer.