GOALI: Coupling Reaction Chemistry with Instrumentation

目标：反应化学与仪器的耦合

• 批准号: 0094568
• 负责人: Julian Tyson
• 金额: $ 23.5万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0094568&HistoricalAwards=false
• 关键词: GOALI; Coupling; Reaction; Chemistry; Instrumentation

Professor Julian Tyson of the University of Massachusetts, Amherst and Dr. Gerhard Schlemmer of Perkin-Elmer Corporation are funded by the Analytical and Surface Chemistry program and the Office of Multidisciplinary Activities for collaborative research on trace analysis involving instrumentation. This Grant Opportunities for Academic Liaison with Industry (GOALI) grant addresses trace element uptake by marine plankton, the fate of arsenic in soils, the anti-cancer properties of selenium-enriched yeast, the uptake of trace elements by marine organisms, the fingerprinting of lead, copper, and gold, and the human metabolism of arsenic, selenium, and mercury. Efforts in the area of sample pre-treatment include microwave and ultrasound-assisted extractions, supercritical extraction, solid phase extraction and liquid/liquid extraction. Specific investigations of flow injection (an area of expertise in the Tyson laboratory) include the evaluation of cationic surfactants on hydride generation and reaction with arsenic and selenite, and development of manifolds for synthesizing volatile organometallic compounds. The PIs propose to develop an interface for HPLC-ICP-MS and liquid-liquid extraction pretreatment. The collaboration will provide industrial experience for students who will spend at least one summer each at Perkin-Elmer in Norwalk, Connecticut or Uberlingen, Germany.Trace element detection is enormously important in the biological, medical and environmental sciences. The difficulty of detecting small amounts of key metals in matrices such as biological fluids and soil still limits our ability to understand transport and function in these media.

马萨诸塞大学，阿默斯特大学的朱利安·泰森（Julian Tyson）和珀金·埃尔默（Perkin-Elmer）公司的格哈德·施莱默（Gerhard Schlemmer）博士由分析和表面化学计划以及多学科活动的办公室资助，用于涉及工具的痕量分析的合作研究。 This Grant Opportunities for Academic Liaison with Industry (GOALI) grant addresses trace element uptake by marine plankton, the fate of arsenic in soils, the anti-cancer properties of selenium-enriched yeast, the uptake of trace elements by marine organisms, the fingerprinting of lead, copper, and gold, and the human metabolism of arsenic, selenium, and mercury. 样品预处理领域的努力包括微波和超声辅助提取物，超临界提取，固相提取以及液体/液体提取。流量注射（泰森实验室的专业知识领域）的具体研究包括评估阳离子表面活性剂在氢化物生成和与砷和亚硒酸盐的反应中的评估，以及用于合成挥发性有机金属化合物的歧管的发展。 PI提议开发用于HPLC-ICP-MS和液体液体提取预处理的界面。 该合作将为学生提供工业经验，这些学生将在诺沃克的Perkin-Elmer度过至少一个夏天的学生。 在诸如生物流体和土壤等矩阵中检测少量的关键金属的困难仍然限制了我们在这些介质中了解运输和功能的能力。