GOALI: Coupling Reaction Chemistry with Instrumentation

马萨诸塞大学阿默斯特分校的Julian Tyson教授和Perkin-Elmer Corporation的Gerhard Schlemmer博士由分析和表面化学计划以及多学科活动办公室资助，以合作研究涉及仪器的痕量分析。这项授予工业学术联系机会(GOALI)的拨款涉及海洋浮游生物对微量元素的吸收、土壤中砷的去向、富硒酵母的抗癌特性、海洋生物对微量元素的吸收、铅、铜和金的指纹，以及人类对砷、硒和汞的新陈代谢。样品前处理方面的努力包括微波和超声波辅助萃取、超临界萃取、固相萃取和液/液萃取。流动注射(泰森实验室的专业领域)的具体研究包括评估阳离子表面活性剂对氢化物生成和与砷和亚硒酸盐反应的影响，以及开发用于合成挥发性有机金属化合物的歧管。PIS建议开发一种用于高效液相-电感耦合等离子体质谱和液-液萃取前处理的接口。这项合作将为那些将在康涅狄格州诺沃克的Perkin-Elmer或德国Uberlingen的Perkin-Elmer度过至少一个暑假的学生提供工业体验。痕量元素检测在生物、医学和环境科学中非常重要。在生物体液和土壤等基质中检测少量关键金属的困难仍然限制了我们理解这些介质中的传输和功能的能力。

Professor Julian Tyson of the University of Massachusetts, Amherst and Dr. Gerhard Schlemmer of Perkin-Elmer Corporation are funded by the Analytical and Surface Chemistry program and the Office of Multidisciplinary Activities for collaborative research on trace analysis involving instrumentation. This Grant Opportunities for Academic Liaison with Industry (GOALI) grant addresses trace element uptake by marine plankton, the fate of arsenic in soils, the anti-cancer properties of selenium-enriched yeast, the uptake of trace elements by marine organisms, the fingerprinting of lead, copper, and gold, and the human metabolism of arsenic, selenium, and mercury. Efforts in the area of sample pre-treatment include microwave and ultrasound-assisted extractions, supercritical extraction, solid phase extraction and liquid/liquid extraction. Specific investigations of flow injection (an area of expertise in the Tyson laboratory) include the evaluation of cationic surfactants on hydride generation and reaction with arsenic and selenite, and development of manifolds for synthesizing volatile organometallic compounds. The PIs propose to develop an interface for HPLC-ICP-MS and liquid-liquid extraction pretreatment. The collaboration will provide industrial experience for students who will spend at least one summer each at Perkin-Elmer in Norwalk, Connecticut or Uberlingen, Germany.Trace element detection is enormously important in the biological, medical and environmental sciences. The difficulty of detecting small amounts of key metals in matrices such as biological fluids and soil still limits our ability to understand transport and function in these media.