GOALI: Coupling Reaction Chemistry with Instrumentation

马萨诸塞大学阿默斯特分校的朱利安·泰森教授和珀金-埃尔默公司的格哈德·施莱默博士由分析和表面化学项目和多学科活动办公室资助，用于涉及仪器的痕量分析的合作研究。这项学术与工业联络的资助机会（GOALI）资助涉及海洋浮游生物对微量元素的吸收、土壤中砷的命运、富硒酵母的抗癌特性、海洋生物对微量元素的吸收、铅、铜和金的指纹识别以及人体对砷、硒和汞的代谢。样品前处理领域的研究包括微波和超声辅助萃取、超临界萃取、固相萃取和液/液萃取。流动注射的具体研究（泰森实验室的专业领域）包括评价阳离子表面活性剂对氢化物的生成和与砷和亚硒酸盐的反应，以及用于合成挥发性有机金属化合物的歧管的开发。建议建立HPLC-ICP-MS和液-液萃取预处理接口。该合作将为学生提供工业经验，他们将在康涅狄格州诺沃克的珀金-埃尔默或德国的乌伯林根度过至少一个夏天。微量元素检测在生物、医学和环境科学中非常重要。在生物流体和土壤等基质中检测少量关键金属的困难仍然限制了我们了解这些介质中的运输和功能的能力。

Professor Julian Tyson of the University of Massachusetts, Amherst and Dr. Gerhard Schlemmer of Perkin-Elmer Corporation are funded by the Analytical and Surface Chemistry program and the Office of Multidisciplinary Activities for collaborative research on trace analysis involving instrumentation. This Grant Opportunities for Academic Liaison with Industry (GOALI) grant addresses trace element uptake by marine plankton, the fate of arsenic in soils, the anti-cancer properties of selenium-enriched yeast, the uptake of trace elements by marine organisms, the fingerprinting of lead, copper, and gold, and the human metabolism of arsenic, selenium, and mercury. Efforts in the area of sample pre-treatment include microwave and ultrasound-assisted extractions, supercritical extraction, solid phase extraction and liquid/liquid extraction. Specific investigations of flow injection (an area of expertise in the Tyson laboratory) include the evaluation of cationic surfactants on hydride generation and reaction with arsenic and selenite, and development of manifolds for synthesizing volatile organometallic compounds. The PIs propose to develop an interface for HPLC-ICP-MS and liquid-liquid extraction pretreatment. The collaboration will provide industrial experience for students who will spend at least one summer each at Perkin-Elmer in Norwalk, Connecticut or Uberlingen, Germany.Trace element detection is enormously important in the biological, medical and environmental sciences. The difficulty of detecting small amounts of key metals in matrices such as biological fluids and soil still limits our ability to understand transport and function in these media.