GOALI: Coupling Reaction Chemistry with Instrumentation

目标：反应化学与仪器的耦合

• 批准号: 0094568
• 负责人: Julian Tyson
• 金额: $ 23.5万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0094568&HistoricalAwards=false
• 关键词: GOALI; Coupling; Reaction; Chemistry; Instrumentation

Professor Julian Tyson of the University of Massachusetts, Amherst and Dr. Gerhard Schlemmer of Perkin-Elmer Corporation are funded by the Analytical and Surface Chemistry program and the Office of Multidisciplinary Activities for collaborative research on trace analysis involving instrumentation. This Grant Opportunities for Academic Liaison with Industry (GOALI) grant addresses trace element uptake by marine plankton, the fate of arsenic in soils, the anti-cancer properties of selenium-enriched yeast, the uptake of trace elements by marine organisms, the fingerprinting of lead, copper, and gold, and the human metabolism of arsenic, selenium, and mercury. Efforts in the area of sample pre-treatment include microwave and ultrasound-assisted extractions, supercritical extraction, solid phase extraction and liquid/liquid extraction. Specific investigations of flow injection (an area of expertise in the Tyson laboratory) include the evaluation of cationic surfactants on hydride generation and reaction with arsenic and selenite, and development of manifolds for synthesizing volatile organometallic compounds. The PIs propose to develop an interface for HPLC-ICP-MS and liquid-liquid extraction pretreatment. The collaboration will provide industrial experience for students who will spend at least one summer each at Perkin-Elmer in Norwalk, Connecticut or Uberlingen, Germany.Trace element detection is enormously important in the biological, medical and environmental sciences. The difficulty of detecting small amounts of key metals in matrices such as biological fluids and soil still limits our ability to understand transport and function in these media.

马萨诸塞大学阿默斯特分校的 Julian Tyson 教授和 Perkin-Elmer Corporation 的 Gerhard Schlemmer 博士受到分析和表面化学项目以及多学科活动办公室的资助，进行涉及仪器的痕量分析的合作研究。 这项学术与工业联络的资助机会 (GOALI) 资助涉及海洋浮游生物对微量元素的吸收、土壤中砷的归宿、富硒酵母的抗癌特性、海洋生物对微量元素的吸收、铅、铜和金的指纹识别，以及砷、硒和汞的人体代谢。 样品前处理领域的工作包括微波和超声辅助萃取、超临界萃取、固相萃取和液/液萃取。流动注射（泰森实验室的专业领域）的具体研究包括评估阳离子表面活性剂对氢化物生成以及与砷和亚硒酸盐的反应，以及开发用于合成挥发性有机金属化合物的歧管。 PI 建议开发一个用于 HPLC-ICP-MS 和液液萃取预处理的接口。 此次合作将为学生提供行业经验，他们将在康涅狄格州诺沃克或德国乌伯林根的珀金埃尔默大学度过至少一个暑假。微量元素检测在生物、医学和环境科学中非常重要。 检测生物体液和土壤等基质中少量关键金属的困难仍然限制了我们了解这些介质中的运输和功能的能力。