Infrared Matrix-assisted Laser Desorption/Ionization Mass Spectrometry

红外基质辅助激光解吸/电离质谱法

• 批准号: 0096457
• 负责人: Kermit Murray
• 金额: $ 33.54万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-15 至 2001-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0096457&HistoricalAwards=false
• 关键词: Infrared; Matrix; assisted; Laser; Desorption

This award to Professor Kermit Murray of Emory University entitled "Infrared Matrix-assisted Laser Desorption/Ionization Mass Spectrometry (IR-MALDI)" is supported by the Analytical and Surface Chemistry Program. The goals of the research are to address fundamental problems in the understanding of IR-MALDI. The research will study wavelength dependence of threshold fluences, ion yields and average initial ion velocities. The investigator will utilize unique two-pulse laser experiments to provide more information and better differentiation between the desorption and ionization processes. In addition the research will include novel applicationssuch as tissue microdissection in conjunction with IR-MALDI and the use of ice matricies for the study of non-covalent complexes.The principle investigator is recognized for his contributions to the community through his widely available internet resources. This research has the potential for high impact in the areas of molecular and cellular biology, as well as, in mass spectrometry.

该奖项授予埃默里大学的Kermit Murray教授，名为“红外矩阵辅助激光解吸/电离质谱（IR-MALDI）”，由分析和表面化学项目支持。这项研究的目的是解决理解IR-MALDI的基本问题。该研究将研究阈值效应、离子产率和平均初始离子速度对波长的依赖性。研究者将利用独特的双脉冲激光实验来提供更多的信息和更好地区分解吸和电离过程。此外，该研究将包括新的应用，如与IR-MALDI结合的组织显微解剖，以及使用冰基质研究非共价复合物。主要研究者通过他广泛可用的互联网资源为他对社区的贡献而得到认可。这项研究在分子和细胞生物学以及质谱学领域具有很高的影响潜力。