Electrochemistry in Ultrasmall Volumes and Magnetohydrodynamic Microfluidics

超小体积电化学和磁流体动力学微流体

• 批准号: 0096780
• 负责人: Ingrid Fritsch
• 金额: $ 38.89万
• 依托单位: University of Arkansas
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2005-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0096780&HistoricalAwards=false
• 关键词: Electrochemistry; Ultrasmall; Volumes; Magnetohydrodynamic; Microfluidics

Professor Ingrid Fritsch of the University of Arkansas is supported by the Analytical and Surface Chemistry Program for her research on electrochemistry in ultrasmall volumes and magnetohydrodynamic (MHD) microfluidics. The research on ultrasmall volumes will attempt to determine the smallest sample size and lowest concentration that can be amperometrically analyzed and how interactions with microfluidics affect such analyses. The effects of proximity of adjacent electrodes and of redox cycling from adjacent electrodes will be examined. Chemical modification of surfaces adjacent to electrodes will be evaluated with respect to immobilization chemistry and electrochemical detection will be studied in separate but closely spaced scenarios. The second thrust will determine the strengths and weaknesses of MHD for microfluidic applications. MHD microfluidics will be driven with an external magnet. On-chip suitability of MHD will be evaluated, and a demonstration system of an immunoassay test system utilizing MHD microfluidics will be constructed.As devices are miniaturized and analytical tests are demanded on chip platforms, the question of how to deliver fluids in tiny volumes becomes a challenge. Studies on ultrasmall volumes are complicated by evaporation and solution manipulation. Implementation of microfluidics methods and development of new ones are immediately needed for microanalysis.

阿肯色州大学的Ingrid Fritsch教授因其对超小体积电化学和磁流体动力学（MHD）微流体的研究而获得分析和表面化学项目的支持。 对超小体积的研究将试图确定可以进行电流分析的最小样本量和最低浓度，以及与微流体的相互作用如何影响这种分析。 将检查相邻电极的接近度和来自相邻电极的氧化还原循环的影响。 将评估电极附近表面的化学改性与固定化化学和电化学检测将在单独但紧密间隔的情况下进行研究。 第二个推力将确定MHD在微流体应用中的优势和劣势。 MHD微流体将由外部磁体驱动。 本项目将对MHD的片上适用性进行评估，并构建利用MHD微流体技术的免疫分析检测系统的演示系统。随着装置的小型化和分析检测的芯片化，如何实现微量流体的输送成为课题。 由于蒸发和溶液处理，对超小体积的研究变得复杂。 微流控方法的实施和新方法的开发是微分析的迫切需要。