Electrochemistry in Ultrasmall Volumes and Magnetohydrodynamic Microfluidics

阿肯色大学的英格丽德·弗里奇教授因其在超小体积和磁流体(MHD)微流体中的电化学研究而得到分析和表面化学计划的支持。对超小体积的研究将试图确定可以进行安培分析的最小样本量和最低浓度，以及与微流体的相互作用如何影响此类分析。将考察相邻电极的接近程度和相邻电极的氧化还原循环的影响。将从固定化化学和电化学检测的角度对电极附近表面的化学修饰进行评估，并将在不同但间隔较近的情况下进行研究。第二个推力将决定MHD在微流控应用中的优势和劣势。MHD微流体将由外部磁铁驱动。将评估磁流体在芯片上的适用性，并将构建一个利用磁流体微流控的免疫分析测试系统的演示系统。随着设备的小型化和分析测试的要求在芯片平台上，如何以微小体积输送流体的问题成为一个挑战。对超小体积的研究由于蒸发和溶液操纵而变得复杂。微分析迫切需要微流控方法的实施和新方法的开发。

Professor Ingrid Fritsch of the University of Arkansas is supported by the Analytical and Surface Chemistry Program for her research on electrochemistry in ultrasmall volumes and magnetohydrodynamic (MHD) microfluidics. The research on ultrasmall volumes will attempt to determine the smallest sample size and lowest concentration that can be amperometrically analyzed and how interactions with microfluidics affect such analyses. The effects of proximity of adjacent electrodes and of redox cycling from adjacent electrodes will be examined. Chemical modification of surfaces adjacent to electrodes will be evaluated with respect to immobilization chemistry and electrochemical detection will be studied in separate but closely spaced scenarios. The second thrust will determine the strengths and weaknesses of MHD for microfluidic applications. MHD microfluidics will be driven with an external magnet. On-chip suitability of MHD will be evaluated, and a demonstration system of an immunoassay test system utilizing MHD microfluidics will be constructed.As devices are miniaturized and analytical tests are demanded on chip platforms, the question of how to deliver fluids in tiny volumes becomes a challenge. Studies on ultrasmall volumes are complicated by evaporation and solution manipulation. Implementation of microfluidics methods and development of new ones are immediately needed for microanalysis.