Electrochemistry in Ultrasmall Volumes and Magnetohydrodynamic Microfluidics

阿肯色大学的Ingrid Fritsch教授在超小体积电化学和磁流体动力学（MHD）微流体方面的研究得到了分析和表面化学项目的支持。对超小体积的研究将试图确定可以进行安培分析的最小样本量和最低浓度，以及与微流体的相互作用如何影响这种分析。相邻电极的接近和相邻电极的氧化还原循环的影响将被检查。电极附近表面的化学修饰将在固定化学和电化学检测方面进行评估，将在单独但紧密间隔的情况下进行研究。第二个推力将决定MHD在微流体应用中的优势和劣势。MHD微流体将由外部磁铁驱动。本研究将评估MHD的片上适用性，并构建MHD微流体免疫分析测试系统的演示系统。随着设备的小型化和分析测试在芯片平台上的需求，如何以小体积输送流体的问题成为一个挑战。由于蒸发和溶液操作，对超小体积的研究变得复杂。微流体分析方法的实施和新方法的开发是迫切需要的。

Professor Ingrid Fritsch of the University of Arkansas is supported by the Analytical and Surface Chemistry Program for her research on electrochemistry in ultrasmall volumes and magnetohydrodynamic (MHD) microfluidics. The research on ultrasmall volumes will attempt to determine the smallest sample size and lowest concentration that can be amperometrically analyzed and how interactions with microfluidics affect such analyses. The effects of proximity of adjacent electrodes and of redox cycling from adjacent electrodes will be examined. Chemical modification of surfaces adjacent to electrodes will be evaluated with respect to immobilization chemistry and electrochemical detection will be studied in separate but closely spaced scenarios. The second thrust will determine the strengths and weaknesses of MHD for microfluidic applications. MHD microfluidics will be driven with an external magnet. On-chip suitability of MHD will be evaluated, and a demonstration system of an immunoassay test system utilizing MHD microfluidics will be constructed.As devices are miniaturized and analytical tests are demanded on chip platforms, the question of how to deliver fluids in tiny volumes becomes a challenge. Studies on ultrasmall volumes are complicated by evaporation and solution manipulation. Implementation of microfluidics methods and development of new ones are immediately needed for microanalysis.