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Small-Scale, Loop-Based Chemical Separations and In-line Sampling Employing Magnetoelectrochemical Methods

采用磁电化学方法的小规模、基于环路的化学分离和在线采样

基本信息

批准号：
1808286
负责人：
Ingrid Fritsch
金额：
$ 45.12万
依托单位：
University of Arkansas
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-01 至 2023-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1808286&HistoricalAwards=false
关键词：
Small Scale Loop Based Chemical

项目摘要

This project is funded by the Chemical Measurement and Imaging Program of the Chemistry Division. Professor Ingrid Fritsch of the University of Arkansas is developing a fast and versatile approach for screening components of crude synthetic mixtures of biologically-relevant chemicals in ultrasmall volumes. This new approach to chemical separations does not require high pressures nor high voltages. It also minimizes expense and improves portability. To meet these separation challenges, magnets and electricity are used to propel the fluid mixtures in the separation system. The system is essentially an indefinitely extended loop where analytes are separated. Each component is removed in a programmable fashion as it pulls away from the others so that separation conditions can be optimized for the rest. This approach advances opportunities for and has economic bearing on drug design, such as in peptide therapeutics, and other chemical products of interest for medical, pharmaceutical, and environmental uses. In an outreach partnership with High School teachers, a self-sustaining summer science workshop, developed by students, for students, focuses on concepts in the research project while highlighting the personalization and humanization of the science.In this project, high-efficiency chemical separations at the small scale with the ability to program column length "on-the-fly" are being developed. Magnetoelectrochemical pumping in loop-based microfluidic channels, combined with ultrasensitive in situ detection of separations, determine conditions for the best separation efficiencies of mixtures focused on therapeutic peptides. Complementary fluorescence techniques are used, including total internal reflection, wide field imaging, and fluorescence correlation spectroscopy. An in-line sampling approach enables near real-time monitoring and tuning of separations. In addition, numerical simulations in three dimensions provide a better understanding of experimental results and suggest designs for improved efficiencies. Personnel at the University of Arkansas partner with a public high school, Haas Hall Academy to initiate and foster a self-sustaining week long summer science workshop. In an outreach partnership with High School teachers, a self-sustaining summer science workshop is under development. Broader impacts to society include facilitation of therapeutic peptide drug design and development through the screening of small quantities of synthetic mixtures with minimal expense.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目由化学部的化学测量和成像计划资助。阿肯色州大学的Ingrid Fritsch教授正在开发一种快速而通用的方法，用于筛选超小体积的生物相关化学品的粗合成混合物的成分。这种新的化学分离方法不需要高压或高压。它还最大限度地减少了费用，提高了便携性。为了应对这些分离挑战，使用磁体和电力来推动分离系统中的流体混合物。该系统基本上是一个无限延伸的环路，其中分析物被分离。每一种组分都以可编程的方式被移除，因为它远离其他组分，因此可以为其余组分优化分离条件。这种方法促进了药物设计的机会，并对药物设计具有经济意义，例如在肽治疗剂和其他用于医疗、制药和环境用途的感兴趣的化学产品中。在与高中教师的外联合作中，由学生为学生开发的自我维持的夏季科学研讨会专注于研究项目中的概念，同时强调科学的个性化和人性化。在该项目中，正在开发具有“即时”编程柱长能力的小规模高效化学分离。基于环路的微流体通道中的磁电化学泵送，结合分离的超灵敏原位检测，确定专注于治疗肽的混合物的最佳分离效率的条件。使用互补荧光技术，包括全内反射、宽视场成像和荧光相关光谱。在线采样方法可实现近实时监测和分离调整。此外，三维数值模拟提供了一个更好的理解实验结果，并建议设计提高效率。阿肯色州大学的工作人员与一所公立高中哈斯霍尔学院合作，发起和促进一个自我维持的为期一周的夏季科学讲习班。在与高中教师的外联伙伴关系中，正在开发一个自我维持的暑期科学讲习班。对社会更广泛的影响包括通过以最小的费用筛选少量合成混合物来促进治疗性肽药物的设计和开发。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估而被认为值得支持。