Structure-Reactivity Relationships in Carbanion Chemistry

碳负离子化学中的结构-反应性关系

• 批准号: 0097197
• 负责人: David Collum
• 金额: --
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2004-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0097197&HistoricalAwards=false
• 关键词: Structure; Reactivity; Relationships; Carbanion; Chemistry

With this renewal award the Organic and Macromolecular Chemistry Program supports the work of Dr. David B. Collum at Cornell University in Ithaca, New York. The work involves a detailed study of the solution structures and reactivities of organolithium aggregates in the presence of N,N,N',N'-tetramethylethylenediamine (TMEDA) and related diamines, as well as ethers such as tetrahydrofuran (THF). The organolithium reagents will include n-BuLi, PhLi, and lithium acetylides. Part of the work will focus on how BF3.amine complexes and other Lewis acid adducts influence the reactivities of the organolithium compounds.Organolithium compounds, containing carbon-lithium bonds, are often written simply as RLi, where R is an organic group. They are used as reagents to prepare a variety of more complex structures, with the formation of new carbon-carbon bonds. The rates of these reactions, and the products formed, depend strongly on the presence of amine, ether, and Lewis acid additives. Dr. Collum and his group are trying to understand what species are present in solution, and how their structures influence their reactivities. The work is likely to be of interest to chemists in both academia and industry, and to provide excellent training for the students involved.

通过这个续展奖项，有机化学和高分子化学项目支持纽约伊萨卡康奈尔大学的戴维·B·科勒姆博士的工作。这项工作包括详细研究有机锂聚集体在N，N，N‘，N’-四甲基乙二胺(TMEDA)和相关的二胺以及四氢呋喃(THF)等乙醚存在下的溶液结构和反应性。有机锂试剂将包括n-BuLi、PhLi和锂乙酰。部分工作将集中在BF3胺络合物和其他Lewis酸加合物如何影响有机锂化合物的反应活性。有机锂化合物，含有碳-锂键，通常简称为RLI，其中R是有机基团。它们被用作试剂来制备各种更复杂的结构，形成新的碳-碳键。这些反应的速度和产物的形成强烈依赖于胺、乙醚和路易斯酸添加剂的存在。科勒姆博士和他的团队正试图了解溶液中存在哪些物种，以及它们的结构如何影响它们的反应性。这项工作可能会引起学术界和工业界化学家的兴趣，并为参与其中的学生提供出色的培训。