Structure-Reactivity Relationships in Carbanion Chemistry

碳负离子化学中的结构-反应性关系

• 批准号: 0650880
• 负责人: David Collum
• 金额: $ 57.2万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0650880&HistoricalAwards=false
• 关键词: Structure; Reactivity; Relationships; Carbanion; Chemistry

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor David B. Collum of Cornell University. This research will involve the study of the structure and reactivity of organolithium reagents in a variety of the solvents typically used for reactions of these species. The way in which these reagents aggregate in solution and how this affects their reactions will be examined. Some of these organolithium reagents are used in the tire industry to initiate polymerization to make synthetic rubber while others are used in the pharmaceutical industry to prepare medicinally important compounds. Broader Impacts. The work carried out has a direct impact on the pharmaceutical industry as evidenced by collaborations with sanofi-Aventis, Pfizer, Merck, Dupont Pharmaceuticals, and Schering-Plough. These efforts are affiliated with a number of drug syntheses including Sustiva (anti-Aids), Chantix (anti-smoking), and Otamixaban (for treatment of acute coronary events). These industrial collaborations will afford students and postdoctoral associates direct contact with the companies involved in these collaborations which will provide them with valuable knowledge when they begin their independent careers especially in the industrial sector. The PI will also continue to give short courses (over twenty to date) to pharmaceutical process chemists. The interactions with these companies will also impact K-12 education in the context of Cornell's "Expanding Your Horizons Program," an on-campus program to promote science to girls in middle school. A considerable percentage of the support for this program comes from, and will continue to come from, Prof. Collum's collaborators and contacts in industry.

有了这个奖项，有机和高分子化学计划支持教授大卫B的工作。康奈尔大学的科拉姆。 本研究将涉及研究有机锂试剂在通常用于这些物质反应的各种溶剂中的结构和反应性。 将检查这些试剂在溶液中聚集的方式以及这如何影响它们的反应。 这些有机锂试剂中的一些用于轮胎工业以引发聚合以制造合成橡胶，而另一些用于制药工业以制备医学上重要的化合物。 更广泛的影响。与赛诺菲安万特、辉瑞、默克、杜邦制药和先灵葆雅的合作证明，所开展的工作对制药行业产生了直接影响。 这些努力与许多药物合成有关，包括Sustiva（抗艾滋病），Chantix（戒烟）和Otamixaban（用于治疗急性冠状动脉事件）。 这些工业合作将使学生和博士后直接接触参与这些合作的公司，这将为他们提供宝贵的知识，当他们开始他们的独立职业生涯，特别是在工业部门。 PI还将继续为制药工艺化学家提供短期课程（迄今为止超过20个）。 与这些公司的互动也将影响K-12教育的背景下，康奈尔大学的“扩大你的视野计划”，一个校园计划，以促进科学的女孩在中学。 对该计划的支持有相当大的比例来自并将继续来自Collum教授的合作者和行业联系人。