Cellular interactions of actin regulatory proteins

肌动蛋白调节蛋白的细胞相互作用

• 批准号: 14721585
• 负责人: Professorin Dr. Angelika A. Noegel
• 金额: --
• 依托单位: Institut für Biochemie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/14721585?language=en
• 关键词: Cellular; interactions; actin; regulatory; proteins

Proteins associated with the actin cytoskeleton provide connections between signalling, adhesion, cell motility and intracellular transport. Many of them have a multidomain structure which allows them to be present within large protein assemblies which link cellular structures to the cytoskeleton and/or to undergo many interactions and perform diverse roles. Goal of this study is to analyse in vivo the interactions of two actin-binding proteins, filamin and CAP (cyclase associated protein). We will specifically look at filamin s potential to sense signals or changes in a cell and will test which kind of self and nonself interactions are important for CAP s in vivo function. The studies will be carried out in Dictyostelium which allows us to use a wide variety of genetic, cell biological and biochemical techniques.

与肌动蛋白细胞骨架相关的蛋白质提供信号传导、粘附、细胞运动和细胞内运输之间的联系。它们中的许多具有多结构域结构，这允许它们存在于将细胞结构连接到细胞骨架的大蛋白质组装体中和/或经历许多相互作用并执行不同的角色。本研究的目的是在体内分析两个肌动蛋白结合蛋白，细丝蛋白和CAP（环化酶相关蛋白）的相互作用。我们将专门研究细丝蛋白在细胞中感知信号或变化的潜力，并测试哪种自我和非自我相互作用对CAP的体内功能很重要。这些研究将在网骨藻中进行，这使我们能够使用各种各样的遗传，细胞生物学和生物化学技术。

项目成果

A Cytohesin Homolog in Dictyostelium Amoebae

盘基网柄菌阿米巴中的细胞粘附素同源物

• DOI: 10.1371/journal.pone.0009378
• 发表时间: 2010
• 期刊: PLoS ONE
• 影响因子: 3.7
• 作者: Müller;Blau-Wasser;Glöckner;Schleicher;Eichinger;Noegel;Kolanus
• 通讯作者: Kolanus

A Coronin7 Homolog with Functions in Actin-driven Processes*

• DOI: 10.1074/jbc.m109.083725
• 发表时间: 2010-01
• 期刊: The Journal of Biological Chemistry
• 作者: M. Shina;C. Ünal;L. Eichinger;A. Müller-Taubenberger;M. Schleicher;M. Steinert;A. Noegel

Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy

• DOI: 10.1007/s00018-012-1142-y
• 发表时间: 2013-02-01
• 期刊: CELLULAR AND MOLECULAR LIFE SCIENCES
• 影响因子: 8
• 作者: Peche, Vivek S.;Holak, Tad A.;Noegel, Angelika A.
• 通讯作者: Noegel, Angelika A.

Microarray phenotyping places cyclase associated protein CAP at the crossroad of signaling pathways reorganizing the actin cytoskeleton in Dictyostelium.

微阵列表型分析将环化酶相关蛋白 CAP 置于重组网柄菌肌动蛋白细胞骨架的信号通路的十字路口

• DOI: 10.1016/j.yexcr.2008.10.023
• 发表时间: 2009
• 期刊: Experimental cell research
• 影响因子: 3.7
• 作者: Sultana;Neelakanta;Eichinger;Rivero;Noegel
• 通讯作者: Noegel

Redundant and unique roles of coronin proteins in Dictyostelium

盘基网柄菌中冠状蛋白的冗余和独特作用

• DOI: 10.1007/s00018-010-0455-y
• 发表时间: 2011
• 期刊: Cellular and Molecular Life Sciences
• 影响因子: 8
• 作者: M. C. Müller-Taubenberger;Schleicher;Steinert;Eichinger;Müller;Blau-Wasser;Glöckner;Noegel
• 通讯作者: Noegel