A Core Equipment Facility for Cellular and Molecular Neuroscience

该合同为购买设备提供支持，用于建立多用户综合核心设备设施，用于细胞和分子生物学研究。该设备包括离心机、显微注射装置、分光光度计和倒置显微镜。该设施将由两个系的教师共享：新成立的细胞生物学和神经科学系以及现有的化学和生物化学系。所有这些研究者的共同焦点是阐明神经发育和/或神经再生的细胞和分子机制。所有这些实验室现在都位于相邻的实验室，考虑到他们研究方法的重叠，他们将能够共享通过该奖项支持的设备。所要求的一些主要设备项目将取代已有近25年历史和严重失修的现有项目，而其他项目将提供新的或扩大的能力。所有主要用户都是NSF赞助的大学IGERT博士培训计划的成员。复杂生物系统课程旨在培养研究生从分子到系统水平的多个层面处理生物问题，使用从细胞和分子生物学，结构生物学，计算生物学和系统神经科学中提取的各种方法。因此，IGERT受训者将大大受益于获得将用于课程作业和论文研究的设备。这些设备也将供一些本科生使用，他们将进行独立的研究项目，作为他们教育的一部分。

This award provides support for purchase of equipment to be used to establish a multi-user, integrated core equipment facility for cellular and molecular biological research. The equipment includes centrifuges, a microinjection apparatus, a spectrophotomer and an inverted microscope. The facility will be shared by faculty in two departments: a newly formed Department of Cell Biology and Neuroscience and an existing Department of Chemistry and Biochemistry. A shared focus of all these investigators is the elucidation of the cellular and molecular mechanisms underlying neural development and/or nerve regeneration. All are now physically located in adjacent labs, and given the overlap in their research methodologies, will be able to share the equipment supported through this award.. Some of the major equipment items requested would replace existing items that are close to 25 years old and in serious disrepair, while others will provide new or expanded capabilities. All major users are members of the NSF sponsored IGERT doctoral training program at the University. This program in Complex Biological Systems is designed to train graduate students to approach biological problems from a multitude of levels, from the molecular to the systems level, using a variety of approaches drawn from cellular and molecular biology, structural biology, computational biology and systems neuroscience. Thus the IGERT trainees will benefit considerably from access to the equipment which will be used in both course work and in thesis research. The equipment will also be available for use by a number of undergraduate students who undertake independent research projects as part of their education.