VOLTAGE-GATED ION CHANNEL PROTEIN RESOURCE DATABASE
VOLTAGE-GATED ION CHANNEL PROTEIN RESOURCE DATABASE
批准号:
0111709
负责人:
Philip Bourne
金额:
$24.0万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-10-01 至 2003-09-30
中文摘要
电压门控通道是材料进出电池的一种方式。它们在整个生物学中都很重要。通道既可以是打开的,也可以是关闭的;这种转换称为门控。然而,这些蛋白质不容易结晶,必须开发二维方法来考虑它们的结构。每个通道蛋白由六个疏水跨膜片段和一个膜插入区组成。预测或至少拥有这些跨膜蛋白的良好模型的能力是研究界的一个重要需求。这方面的技术现在才刚刚开始。目前,由于结晶困难,PDB中没有VGC蛋白的良好同源物。然而,序列比对是可能的。利用该小组开发的各种软件包,将从这些比对的序列中开发出三维蛋白质同源模型。由此产生的工具将在网络上提供。一旦建立了第一个模型,就可以自动预测所有相似排列的蛋白质。这一努力将产生模型,这些模型可以用来改进来自新的研究和考虑膜蛋白的方法的结构数据。
英文摘要
Voltage gated channels are one of the ways that materials move into and out of cells. They are important across biology. A channel can either be open or closed; the transition is called gating. However, these proteins do not crystallize easily and two-dimensional methods have had to be developed to consider their structure. Each channel protein consists of six hydrophobic membrane-spanning segments and a membrane insertion region. The ability to predict or at least have good models for these transmembrane proteins is a significant need for the research community. The techniques for this are now just beginning. At the moment, there are no good homologues to VGC proteins in the PDB, because of the difficulty of crystallization. However, alignment of sequence is possible. Three-dimensional protein homology models will be developed from these aligned sequences, using a variety of software packages developed by the group. The resulting tools will be available on the web. Once the first models are made, all similarly aligned proteins can be automatically predicted. This effort will produce models that could be used to refine the structure data coming from new studies and methods of considering membrane proteins.
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会议论文
Conceptualization and Analysis of a 3D Virtual Cell
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批准号:1216893
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项目类别:Standard Grant
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资助金额:$62.58万
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财政年份:2012
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负责人:Philip Bourne
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依托单位:
SGER: SciTube.tv: Video Delivery of Papers Published in PLoS Journals
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批准号:0732706
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项目类别:Standard Grant
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资助金额:$0.0万
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财政年份:2007
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负责人:Philip Bourne
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依托单位:
CyberBridge
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批准号:0737714
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项目类别:Continuing Grant
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资助金额:$119.56万
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财政年份:2007
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负责人:Philip Bourne
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依托单位:
ISMB Conference Support for Students & Young Scientists
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批准号:0620405
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项目类别:Standard Grant
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资助金额:$4.0万
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财政年份:2006
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负责人:Philip Bourne
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依托单位:
BioLit: Open Source Tools for Integrating Biological Literature and Databases
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批准号:0544575
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项目类别:Continuing Grant
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资助金额:$95.35万
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财政年份:2006
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负责人:Philip Bourne
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依托单位:
ISMB Conference on June 25-29, 2005 in Detroit, Michigan. Support for Students & Young Scientists
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批准号:0505980
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项目类别:Standard Grant
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资助金额:$3.0万
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财政年份:2005
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负责人:Philip Bourne
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依托单位:
ISMB 2004 Conference Support for Students and Young Scientists, to be held in Glasgow, Scotland July 2004.
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批准号:0440678
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项目类别:Standard Grant
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资助金额:$5.52万
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财政年份:2004
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负责人:Philip Bourne
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依托单位:
A Public Database Linking Protein Structure and Sequence Mutation Data
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批准号:0111710
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项目类别:Continuing Grant
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资助金额:$54.27万
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财政年份:2001
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负责人:Philip Bourne
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依托单位:
A Public Database Resource for Apoptosis Research and Education
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批准号:0078731
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项目类别:Continuing Grant
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资助金额:$51.88万
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财政年份:2000
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负责人:Philip Bourne
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依托单位:
Molecular Interactive Collaborative Environment (MICE)
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批准号:9723475
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项目类别:Standard Grant
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资助金额:$45.01万
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财政年份:1997
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负责人:Philip Bourne
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依托单位:
A Portable Client-Server Data Management System for the Comparative Analysis of Proteins
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批准号:9630339
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项目类别:Standard Grant
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资助金额:$42.44万
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财政年份:1996
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负责人:Philip Bourne
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依托单位:
International Summer School on Macromolecular Crystallographic Computing being held at Western Washington University in Bellingham, WA., August 16-22, 1996
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批准号:9529557
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项目类别:Standard Grant
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资助金额:$0.5万
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财政年份:1996
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负责人:Philip Bourne
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依托单位:
Continued Development of a Software Framework to Maintain and Query Features of Biological Macromolecules
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批准号:9507625
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项目类别:Standard Grant
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资助金额:$14.1万
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财政年份:1995
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负责人:Philip Bourne
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依托单位:
CIFters: Object Oriented Tools for Manipulating Crystallographic Information Files (CIF)
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批准号:9310154
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项目类别:Continuing Grant
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资助金额:$39.19万
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财政年份:1993
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负责人:Philip Bourne
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依托单位:
An Object-Oriented Toolbox for Use with the Protein Data Bank (PDB)
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批准号:9116798
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项目类别:Continuing Grant
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资助金额:$114.68万
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财政年份:1992
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负责人:Philip Bourne
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依托单位:
海外基金