VOLTAGE-GATED ION CHANNEL PROTEIN RESOURCE DATABASE

电压门控通道是材料进出电池的一种方式。它们在整个生物学中都很重要。通道既可以是打开的，也可以是关闭的；这种转换称为门控。然而，这些蛋白质不容易结晶，必须开发二维方法来考虑它们的结构。每个通道蛋白由六个疏水跨膜片段和一个膜插入区组成。预测或至少拥有这些跨膜蛋白的良好模型的能力是研究界的一个重要需求。这方面的技术现在才刚刚开始。目前，由于结晶困难，PDB中没有VGC蛋白的良好同源物。然而，序列比对是可能的。利用该小组开发的各种软件包，将从这些比对的序列中开发出三维蛋白质同源模型。由此产生的工具将在网络上提供。一旦建立了第一个模型，就可以自动预测所有相似排列的蛋白质。这一努力将产生模型，这些模型可以用来改进来自新的研究和考虑膜蛋白的方法的结构数据。

Voltage gated channels are one of the ways that materials move into and out of cells. They are important across biology. A channel can either be open or closed; the transition is called gating. However, these proteins do not crystallize easily and two-dimensional methods have had to be developed to consider their structure. Each channel protein consists of six hydrophobic membrane-spanning segments and a membrane insertion region. The ability to predict or at least have good models for these transmembrane proteins is a significant need for the research community. The techniques for this are now just beginning. At the moment, there are no good homologues to VGC proteins in the PDB, because of the difficulty of crystallization. However, alignment of sequence is possible. Three-dimensional protein homology models will be developed from these aligned sequences, using a variety of software packages developed by the group. The resulting tools will be available on the web. Once the first models are made, all similarly aligned proteins can be automatically predicted. This effort will produce models that could be used to refine the structure data coming from new studies and methods of considering membrane proteins.