A Public Database Linking Protein Structure and Sequence Mutation Data

蛋白质突变是进化过程的一部分，通过诱变和翻译后修饰发生。到目前为止，尽管文献中充满了个体实例，但还没有开发出能够系统研究所有这些突变对蛋白质结构和功能的影响的资源。新资源将包含所有相关的PDB结构作为其起点，并将与PDB一起更新。在http://pmr.sdsc.edu上建立了一个原型。该生产资源将利用新颖的信息获取工具汇集序列、结构和文献信息，并为突变效应的全局分析提供查询和可视化工具。通过利用资源进行预测和方法确认，将加强蛋白质结构和工程方面的研究。资源可以通过网络访问，其他用户可以编写软件来直接查询资源。

Protein mutation occurs as part of the evolutionary process, through mutagenesis and through post-translational modification. As yet no resource has been developed that permits the systematic study of the effect of all these mutations on protein structure, and hence function, even though the literature is full of individual instances. The new resource will contain all relevant PDB structures as its starting point and will be updated along with PDB. A prototype has been established at http://pmr.sdsc.edu. The production resource will bring together sequence, structure, and literature information using novel information acquisition tools and provide query and visualization tools for global analysis of the effects of mutation. Research in protein structure and engineering will be enhanced through using the resource for prediction and for confirmation of methods. The resource will be accessible through the web and other users may write software for doing direct querying of the resource.