A Public Database Resource for Apoptosis Research and Education

用于细胞凋亡研究和教育的公共数据库资源

• 批准号: 0078731
• 负责人: Philip Bourne
• 金额: $ 51.88万
• 依托单位: Sanford Burnham Prebys Medical Discovery Institute
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0078731&HistoricalAwards=false
• 关键词: Public; Database; Resource; Apoptosis; Research

Apoptosis (programmed cell death) research is currently among the three fastest growing topics in worldwide biomedical research. Apoptosis plays a critical role in a wide variety of normal physiological processes. Significant data and knowledge are being accumulated on the complex apoptotic pathway, yet no resource exists to appropriately collate this information for the purposes of education and research. With extremely rapid growth of the available experimental data, the problem with redundant research is growing as illustrated with conflicting nomenclature and multiple re-discovery of the same proteins by independent groups.This project assists a rapidly growing community of apoptosis research by providing a public, WEB based resource that brings together all available information about apoptosis and its related proteins. In particular, the resource will contain a searchable database containing information about the following:-Families of proteins involved in apoptosis, including their domain structure, phylogenetic relations, and functional motifs.-Links to literature describing specific experiments with details about function of all proteins.-Three-dimensional structure (or predicted structure) of apoptosis related proteins.-Lists of uncharacterized proteins with domains known for their role in apoptosis.Expertise of leading apoptosis researchers is used to develop the preliminary version of the databases that are then supported by automated methods for finding new sequences, structures, and text information related to apoptosis that appear in various Internet-accessible resources. Once implemented, these automate as far as possible the collection of current, well-annotated data on apoptosis for a worldwide community of users. In addition, novel algorithms for structure and function prediction from sequence are used to enhance existing information with hypotheses about structure and molecular mechanism of function of apoptosis-related proteins, helping to plan and develop new experiments. This project thus provides the rapidly growing community of apoptosis research an access to consistently complete and current data. The prototype resource can be found at http://apoptosis-db.org.

细胞凋亡（程序性细胞死亡）研究是目前全球生物医学研究中增长最快的三个主题之一。 细胞凋亡在多种正常生理过程中起着至关重要的作用。 关于复杂的细胞凋亡途径的大量数据和知识正在积累，但没有资源可以出于教育和研究的目的适当整理这些信息。 随着可用实验数据的极快增长，冗余研究的问题日益严重，如相互冲突的命名法和独立团体对相同蛋白质的多次重新发现所表明的那样。该项目通过提供一个公共的、基于 WEB 的资源来帮助快速增长的细胞凋亡研究社区，该资源汇集了有关细胞凋亡及其相关蛋白质的所有可用信息。 特别是，该资源将包含一个可搜索数据库，其中包含以下信息：-参与细胞凋亡的蛋白质家族，包括其结构域结构、系统发育关系和功能基序。-描述特定实验的文献链接，其中包含所有蛋白质功能的详细信息。-细胞凋亡相关蛋白质的三维结构（或预测结构）。-具有已知作用域的未表征蛋白质列表 领先的细胞凋亡研究人员的专业知识用于开发数据库的初步版本，然后由自动化方法支持，用于查找出现在各种互联网可访问资源中的与细胞凋亡相关的新序列、结构和文本信息。 一旦实施，这些将尽可能自动化地为全球用户社区收集最新的、注释良好的细胞凋亡数据。 此外，利用序列预测结构和功能的新算法，通过关于凋亡相关蛋白的结构和分子功能机制的假设来增强现有信息，有助于规划和开发新的实验。 因此，该项目为快速增长的细胞凋亡研究团体提供了获得一致完整的最新数据的途径。 原型资源可以在 http://apoptosis-db.org 找到。