Mechanisms of Transition Metal Catalyzed Reactions in Hydrocarbons

这个项目继续探索有机金属烯烃复分解反应，这已经成为现代合成化学家的关键工具之一。 应用包括合成小分子，如天然产物，以及生产具有明确结构和可控性能的聚合物。 在目前的拨款期间，重点将放在发展这些反应的基本机制基础的更充分的理解。 除了其内在的科学价值外，预计这些研究还将产生新催化剂体系的进一步改进和开发。 该奖项将由化学系的有机和高分子化学项目以及材料研究系的固态化学和聚合物项目共同资助，以支持Robert H.加州理工学院的格拉布斯。 Grubbs教授开发了非常强大的催化剂，用于精确构建有机分子，包括制药和聚合物工业所感兴趣的那些分子。 目前的供资期将允许进一步了解和改进所需的催化剂系统及其在制备新型聚合物中的应用。

This project continues the exploration of organometallic olefin metathesis reactions, which has grown into one of the key tools of modern synthetic chemists. Applications include the synthesis of small molecules, such as natural products, and the production of polymers with well-defined structures and controlled properties. During the current granting period, emphasis will be placed on developing a fuller understanding of the fundamental mechanistic underpinnings of these reactions. Further refinement and development of new catalyst systems are expected to accrue from such studies, in additional to their intrinsic scientific value. Applications of a tandem strategy coupling ring-opening metathesis with atom transfer radical polymerization will be used to produce a variety of new polymer structures such as comb and hyper-branched systems.With this Award, the Organic and Macromolecular Chemistry Program of the Division of Chemistry and the Solid State Chemistry and Polymers Program of the Division of Materials Research support the research activities of Professor Robert H. Grubbs of the California Institute of Technology. Professor Grubbs has developed very powerful catalysts for the precise construction of organic molecules including those of interest to the pharmaceutical and polymer industries. The current period of funding will allow for the further understanding and refinement of the needed catalyst systems as well as their applications for the preparation of novel polymeric substances.