Development and Construction of Single Molecule Force Spectrometers for Research and Student Training

用于研究和学生培训的单分子力谱仪的开发和构建

• 批准号: 0114703
• 负责人: Stefan Zauscher
• 金额: $ 17.33万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-15 至 2003-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0114703&HistoricalAwards=false
• 关键词: Development; Construction; Single; Molecule; Force

This award from the Instrumentation for Materials Research program supports the construction of a suite of four single-molecule force spectrometers for development, training and research to be shared by the Departments of Mechanical Engineering, Chemistry, and Biochemistry at Duke University. These instruments permit the measurement of very weak forces (tens of picoNewtons) on the spectrometer tip as a function of its distance from a surface (controlled to 0.3 nm), so that the properties of individual molecules can be studied. In-house construction of the instruments will provide the expertise necessary to modify and develop the facility to meet future educational and research needs. The presence of multiple instruments provides the resources necessary to allow concurrent development and training while still meeting the research needs of the users. Students from each of the represented disciplines will receive training in the development and/or use of single-molecule force spectrometry, an area of growing importance in fundamental research, biotechnology and materials science. No such general training opportunity presently exists on campus. The facility will be centrally located to encourage interactions and collaborations between users from all disciplines, and these interactions will be fostered through a course in macromolecular interactions to be taught and supervised by faculty from each department.This award from the Instrumentation for Materials Research program supports the construction of a suite of four single-molecule force spectrometers for development, training and research to be shared by the Departments of Mechanical Engineering, Chemistry, and Biochemistry at Duke University. These instruments permit the measurement of very weak forces (tens of piconewtons) on the spectrometer tip as a function of its distance from a surface (controlled to a fraction of a nanometer), so that the properties of individual molecules can be studied. In-house construction of the instruments will provide the expertise necessary to modify and develop the facility to meet future educational and research needs. The presence of multiple instruments provides the resources necessary to allow concurrent development and training while still meeting the research needs of the users. Students from each of the represented disciplines will receive training in the development and/or use of single-molecule force spectrometry, an area of growing importance in fundamental research, biotechnology and materials science. No such general training opportunity presently exists on campus. The facility will be centrally located to encourage interactions and collaborations between users from all disciplines, and these interactions will be fostered through a course in macromolecular interactions to be taught and supervised by faculty from each department.

材料研究仪器计划的这一奖项支持建造一套四个单分子力谱仪，用于杜克大学机械工程，化学和生物化学系的开发，培训和研究。这些仪器允许测量光谱仪尖端上非常微弱的力（数十皮牛顿），作为其与表面距离的函数（控制到0.3 nm），以便可以研究单个分子的性质。 仪器的内部建设将提供必要的专业知识，以修改和开发该设施，以满足未来的教育和研究需要。 多个仪器的存在提供了必要的资源，允许同时进行开发和培训，同时仍然满足用户的研究需求。来自每个学科的学生将接受单分子力谱法的开发和/或使用方面的培训，这是基础研究，生物技术和材料科学中日益重要的领域。 目前在校园里没有这样的培训机会。该设施将位于中心位置，以鼓励来自所有学科的用户之间的互动和合作，这些互动将通过大分子相互作用课程来培养，该课程将由各部门的教师教授和监督。材料研究仪器计划的这一奖项支持建造一套四台单分子力谱仪用于开发，培训和研究将由杜克大学的机械工程，化学和生物化学系共享。这些仪器允许测量光谱仪尖端上非常微弱的力（数十微微牛顿），作为其与表面距离的函数（控制到纳米的几分之一），以便可以研究单个分子的性质。 仪器的内部建设将提供必要的专业知识，以修改和开发该设施，以满足未来的教育和研究需要。 多个仪器的存在提供了必要的资源，允许同时进行开发和培训，同时仍然满足用户的研究需求。来自每个学科的学生将接受单分子力谱法的开发和/或使用方面的培训，这是基础研究，生物技术和材料科学中日益重要的领域。 目前在校园里没有这样的培训机会。该设施将位于中心位置，以鼓励来自所有学科的用户之间的互动和合作，这些互动将通过大分子相互作用课程来培养，由每个部门的教师教授和监督。