NSF-Europe Materials Collaboration: Synthesis, Characterization and Molecular Modeling of Stimulus-Responsive Polymer Brushes on Surfaces
NSF-欧洲材料合作:表面刺激响应聚合物刷的合成、表征和分子建模
基本信息
- 批准号:0502953
- 负责人:
- 金额:$ 33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2005
- 资助国家:美国
- 起止时间:2005-06-15 至 2009-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
INTELLECTUAL MERITSThe objective of the project is to design, fabricate and characterize novel, stimulus-responsivepolymer brushes that can be controlled on the molecular length scale. To capitalize on the potential of these stimulus-responsive polymer brush nanostructures, there is a need to understand how molecularscale structural characteristics influence the conformational properties and the hydration dynamics. Furthermore, efficient methods need to be devised to impart this molecular functionality to a variety of surfaces. Model systems with controlled chain length, surface density and surface structure are required in conjunction with theoretical models and experimentally convenient methods to study the conformational mechanics of these polymer systems. The proposed research addresses these needs by tackling three specific aims in the framework of a strong, international collaboration between Duke University, Lund University and the Neutron Research Laboratory (NFL) at Uppsala University.SA 1: Synthesis of new, stimulus-responsive brushes and nanostructuresSA 2:Characterization of the effect of molecular architecture on brush conformation and conformational dynamics using QCM-D/ellipsometry and neutron reflection measurements.SA 3: Study of lateral interactions in polymer brush nanostructures through experiments and modeling The results from the proposed activities will contribute significantly to the fundamental understanding of structure-property relationships in stimulus-responsive polymer brushes and nanostructures on surfaces.BROADER IMPACTS AND INTERNATIONAL COLLABORATIONIn a larger context, the activities outlined in the two interlinked proposals are directed atengineering and controlling the surface chemistry and topography of nanostructured polymeric surfaces in three dimensions. The use of powerful characterization techniques, such as NR, will illuminate the role of molecular architecture on the conformation behavior of copolymer brushes and will likely result in design guidelines for stimulus-responsive polymer brushes. Whereas the proposed combination of QCMD and ellipsometry measurements potentially has more far reaching impact, as it likely can be applied to biomolecular recognition systems, were the combined measurement will reveal insight into the conformational dynamics and the changes in the hydration state upon ligand binding. Molecular modeling will develop tools that can be used to predict and design the conformational response of nanostructured polymeric surfaces.The proposed research offers a great opportunity to further establish and strengthen a researchand education linkage between Lund University and Duke University. From the range of activitiesproposed it is clear that the research is interdisciplinary and clearly addresses fundamental polymermaterials phenomena, in addition to novel concepts in materials characterization and synthesis. The scope of the proposed activities is extremely well matched with the combined expertise of the participants. A significant objective of the proposed project is the involvement of student and junior researchers (post docs) in an international research and education experience. The administration of both universities pledged to accredit research and class credits taken by students at the respective partner university. Mutual, extended visits are planned that will strengthen the scientific collaboration but also provide a mechanism to expose students and junior researchers to a significant cultural experience abroad.
该项目的目标是设计,制造和表征新的,刺激响应聚合物刷,可以控制的分子长度尺度。为了利用这些刺激响应聚合物刷纳米结构的潜力,有必要了解分子尺度的结构特征如何影响构象特性和水合动力学。此外,需要设计有效的方法来将这种分子功能赋予各种表面。控制链长,表面密度和表面结构的模型系统需要结合理论模型和实验方便的方法来研究这些聚合物系统的构象力学。拟议的研究通过在杜克大学、隆德大学和乌普萨拉大学中子研究实验室(NFL)之间的强大国际合作框架内解决三个具体目标来满足这些需求。SA 1:新型刺激响应刷和纳米结构的合成SA 2:使用QCM-D/椭圆偏振法和中子反射测量表征分子结构对刷构象和构象动力学的影响SA 3:通过实验和建模研究聚合物刷纳米结构中的横向相互作用所提出的活动的结果将大大有助于对表面上的刺激响应聚合物刷和纳米结构的结构-性质关系的基本理解。更广泛的影响和国际合作在更大的背景下,在这两个相互关联的提案中概述的活动是针对在三维空间中增强和控制纳米结构聚合物表面的表面化学和形貌。使用强大的表征技术,如NR,将阐明分子结构对共聚物刷的构象行为的作用,并可能导致刺激响应聚合物刷的设计指南。然而,所提出的QCMD和椭圆偏振测量的组合可能具有更深远的影响,因为它可能可以应用于生物分子识别系统,组合测量将揭示配体结合时的构象动力学和水合状态的变化。分子模拟将开发可用于预测和设计纳米结构聚合物表面的构象响应的工具。拟议的研究为进一步建立和加强隆德大学和杜克大学之间的研究和教育联系提供了一个很好的机会。从提出的活动范围来看,很明显,这项研究是跨学科的,除了材料表征和合成方面的新概念外,还明确涉及基本的聚合物材料现象。拟议活动的范围与与会者的综合专门知识极为匹配。拟议项目的一个重要目标是学生和初级研究人员(博士后)参与国际研究和教育经验。这两所大学的行政部门承诺认可学生在各自伙伴大学取得的研究和课程学分。计划进行相互的长期访问,这将加强科学合作,但也提供了一种机制,使学生和初级研究人员能够在国外获得重要的文化体验。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stefan Zauscher其他文献
Normal Forces between Cellulose Surfaces Measured with Colloidal Probe Microscopy.
用胶体探针显微镜测量纤维素表面之间的法向力。
- DOI:
10.1006/jcis.2000.7008 - 发表时间:
2000 - 期刊:
- 影响因子:9.9
- 作者:
Stefan Zauscher;D. Klingenberg - 通讯作者:
D. Klingenberg
Visualizing Lipid Reactivity of HIV-1 Antigen and Neutralizing Antibodies using Atomic Force Microscopy
- DOI:
10.1016/j.bpj.2011.11.1673 - 发表时间:
2012-01-31 - 期刊:
- 影响因子:
- 作者:
Gregory J. Hardy;Munir Alam;Joe Shapter;Stefan Zauscher - 通讯作者:
Stefan Zauscher
Emerging applications of stimuli-responsive polymer materials
刺激响应性聚合物材料的新兴应用
- DOI:
10.1038/nmat2614 - 发表时间:
2010-01-22 - 期刊:
- 影响因子:38.500
- 作者:
Martien A. Cohen Stuart;Wilhelm T. S. Huck;Jan Genzer;Marcus Müller;Christopher Ober;Manfred Stamm;Gleb B. Sukhorukov;Igal Szleifer;Vladimir V. Tsukruk;Marek Urban;Françoise Winnik;Stefan Zauscher;Igor Luzinov;Sergiy Minko - 通讯作者:
Sergiy Minko
Stefan Zauscher的其他文献
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{{ truncateString('Stefan Zauscher', 18)}}的其他基金
Collaborative Research: Supramolecular Materials by Nucleic Acid Block Copolymer Self-Assembly
合作研究:核酸嵌段共聚物自组装超分子材料
- 批准号:
1411126 - 财政年份:2014
- 资助金额:
$ 33万 - 项目类别:
Continuing Grant
2014 GRC/GRS Biointerface Science: Engineered Biomolecular Interfaces, June 14-20, 2014
2014 GRC/GRS 生物界面科学:工程生物分子界面,2014 年 6 月 14-20 日
- 批准号:
1419278 - 财政年份:2014
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
MRI Consortium: Acquisition of X-Ray Scattering Instrumentation - SAXS/WAXS/GISAXS
MRI 联盟:收购 X 射线散射仪器 - SAXS/WAXS/GISAXS
- 批准号:
1229560 - 财政年份:2012
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
2012 Biointerface Science GRC/GRS, May 19 - 20, 2012 and May 19 - 25, 2012, Les Diablerets, Switzerland
2012 Biointerface Science GRC/GRS,2012年5月19日至20日和2012年5月19日至25日,莱迪亚布勒雷,瑞士
- 批准号:
1213201 - 财政年份:2012
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
Triangle Center for Excellence for Materials Research and Innovation: Programmable Assembly of Soft Matter
三角材料研究与创新卓越中心:软物质的可编程组装
- 批准号:
1121107 - 财政年份:2011
- 资助金额:
$ 33万 - 项目类别:
Cooperative Agreement
GOALI Collaborative Research: Engineering magnetorheological fluids by controlling nonmagnetic particle interactions
GOALI 合作研究:通过控制非磁性粒子相互作用来设计磁流变流体
- 批准号:
0932715 - 财政年份:2009
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
International Symposium Support for the Biomaterial Interfaces Division of the AVS; San Jose, CA
对 AVS 生物材料界面部门的国际研讨会支持;
- 批准号:
0942877 - 财政年份:2009
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
CAREER: Fabrication and Characterization of Stimulus-Responsive Polymer Nanostructures
职业:刺激响应聚合物纳米结构的制造和表征
- 批准号:
0239769 - 财政年份:2003
- 资助金额:
$ 33万 - 项目类别:
Continuing Grant
Development and Construction of Single Molecule Force Spectrometers for Research and Student Training
用于研究和学生培训的单分子力谱仪的开发和构建
- 批准号:
0114703 - 财政年份:2001
- 资助金额:
$ 33万 - 项目类别:
Standard Grant
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