MRI: Acquisition of a Magnetic Resonance Imaging Accessory for a Bruker 400 MHz NMR Spectrometer

MRI：为 Bruker 400 MHz NMR 波谱仪购买磁共振成像附件

• 批准号: 0116263
• 负责人: Nancy Kolodny
• 金额: $ 18.46万
• 依托单位: Wellesley College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0116263&HistoricalAwards=false
• 关键词: MRI; Acquisition; Magnetic; Resonance; Imaging

Acquisition of a Magnetic Resonance Imaging Accessory for a 400 MHz NMR Spectrometer: Interdisciplinary Research in MRI in an Undergraduate College SettingABSTRACTA grant has been awarded to Dr. Nancy H. Kolodny and her colleagues at Wellesley College, an undergraduate liberal arts college for women, to establish a Magnetic Resonance Micro-Imaging Facility in Wellesley's Science Center. This facility will offer unique interdisciplinary research, teaching, and learning opportunities to Wellesley's faculty and students, with initial research projects in the emerging field of neuroscience. With the establishment of the micro-imaging facility, two different types of Magnetic Resonance Imaging (MRI) techniques, functional MRI (fMRI) and contrast enhanced MRI will be developed. These techniques will be used to answer important neurobiological questions. Functional MRI will be utilized to examine the brains of crustaceans such as lobsters, and mice. Details of activity patterns in the olfactory pathway of the crustacean brain will be elucidated. In mice, the question of whether gender and age affect brain function will be investigated, focusing on the response of the brain to stimulation of the whisker barrels. Contrast enhancement techniques will be used to address questions related to the role of serotonin, an important brain biochemical, in olfactory neurons in newborn crustaceans. An MRI experiment will be introduced into Wellesley's undergraduate introductory developmental biology course. Students will use MRI to explore the pupal development of tobacco hawkmoth. Not only will this give students experience with MRI, it will also provide an opportunity for dynamic observation of living organisms during development. The scientific problems to be examined in the new Magnetic Resonance Micro-Imaging Facility at Wellesley College are of importance in the developing basic understanding of brain and neuron function. Furthermore, training undergraduate students in the use of MRI will both inspire them to further study of science and enable them to pursue sophisticated research during their college years and beyond.

为400 MHz核磁共振波谱仪采购磁共振成像附件：在本科学院环境中进行核磁共振的跨学科研究ABSTRACTA已向卫尔斯理学院的Nancy H.Kolodny博士和她的同事授予赠款，用于在韦尔斯利科学中心建立磁共振显微成像设施。该设施将为卫尔斯理的教职员工和学生提供独特的跨学科研究、教学和学习机会，并在新兴的神经科学领域开展初步研究项目。随着显微成像设备的建立，将发展两种不同类型的磁共振成像(MRI)技术：功能磁共振成像(FMRI)和增强磁共振成像(MRI)。这些技术将用于回答重要的神经生物学问题。功能核磁共振将被用于检查龙虾和老鼠等甲壳类动物的大脑。甲壳类动物大脑嗅觉通路的活动模式的细节将被阐明。在老鼠身上，性别和年龄是否会影响大脑功能的问题将被研究，重点是大脑对胡须桶刺激的反应。对比度增强技术将用于解决与5-羟色胺有关的问题，5-羟色胺是一种重要的大脑生化物质，在新生甲壳类动物的嗅觉神经元中扮演着重要的角色。一项核磁共振实验将被引入韦尔斯利的本科生发育生物学入门课程。学生将使用核磁共振技术来探索烟草鹰蛾的蛹发育。这不仅将给学生提供核磁共振的体验，还将为动态观察发育过程中的生物提供机会。将在韦尔斯利学院新的磁共振显微成像设备中研究的科学问题对于发展对大脑和神经元功能的基本理解具有重要意义。此外，培训本科生使用核磁共振成像将激励他们进一步学习科学，并使他们能够在大学期间和以后从事复杂的研究。