MRI: Acquisition of 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer Console and Probe to Bolster Excellence in Undergraduate Research

该奖项由主要研究仪器和化学研究仪器项目联合支持。罗德学院正在购买一台带有宽带探头的400兆赫核磁共振（NMR）光谱仪的升级控制台，以支持Larryn Peterson教授和同事William R. Eckenhoff的研究。该仪器促进了有机、生物有机和无机化学领域的研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。该仪器加强了罗德学院各级学生的教育、研究和教学工作，并为LeMoyne-Owen学院提供了使用便利。该文书加强了这些机构中代表性不足群体的招聘和参与研究和教学工作。核磁共振谱仪奖旨在加强各级的研究和教育，特别是在有机、生物有机和无机小分子研究方面。该仪器影响了多种研究项目，包括开发高活性的富土金属质子还原催化剂，设计和合成多巴胺衍生物和其他儿茶酚作为酶功能探针。它还协助动物毒液抗菌肽的合成、表征和生物活性研究，以及新型非天然氨基酸和突变肽的合成，以确定FNII和CTLD1结构域。此外，该仪器还有助于LpxC酶抑制剂的设计、芳基酮氧化成羧酸的新方法、亚甲基苯胺羟肟酸（SAHA）硼酸类似物的合成，以及有机化学实验室基于课程的本科生研究经验的发展。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Rhodes College is acquiring an upgraded console for a 400 MHz nuclear magnetic resonance (NMR) spectrometer with a broadband probe to support the research of Professor Larryn Peterson and colleague William R. Eckenhoff. This instrument facilitates research in the areas of organic, bioorganic, and inorganic chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument enhances the educational, research, and teaching efforts of students at all levels at Rhodes College as well as provides accessibility for use at LeMoyne-Owen College. This instrument enhances the recruitment and engagement in research and teaching for underrepresented groups at these institutions. The award of the NMR spectrometer is aimed at enhancing the research and education at all levels, especially in organic, bioorganic, and inorganic small molecule research. The instrument impacts a variety of research projects including the development of highly active proton reduction catalysts with earth abundant metals and the design and synthesis of dopamine derivatives and other catechols as probes for enzyme function. It also assists with the synthesis, characterization, and biological activity studies of antimicrobial peptides from animal venoms, and the synthesis of novel unnatural amino acids and mutated peptides to determine FNII and CTLD1 domains. Additionally, the instrument facilitates the design of inhibitors of the LpxC enzyme, new methods to oxidize aryl ketones to carboxylic acids, the synthesis of boronic acid analogues of suberoylanilide hydroxamic acid (SAHA), and the development of course-based undergraduate research experiences for the organic chemistry laboratory.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.