MRI: Acquisition of a Pulsed Electron and Nuclear Magnetic Resonance Spectrometer

MRI：脉冲电子和核磁共振波谱仪的采集

• 批准号: 2216355
• 负责人: Claudia Avalos
• 金额: $ 32.7万
• 依托单位: New York University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216355&HistoricalAwards=false
• 关键词: MRI; Acquisition; Pulsed; Electron; Nuclear

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. New York University is upgrading the electronics of a X-band Electron Paramagnetic Resonance (EPR) spectrometer to include pulsed EPR equipped with Overhauser Dynamic Nuclear Polarization (ODNP) Nuclear Magnetic Resonance (NMR) detection to support the research of Professor Claudia Avalos and colleagues Bart E. Kahr and Stephanie Lee. This instrument facilitates research in the areas of biochemistry, biophysics, and material science. The proposed instrument combines three techniques: electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), and Overhauser dynamic nuclear polarization (ODNP). An EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid state materials. It may also be used to obtain information about the lifetimes of short-lived, highly reactive species involved in important chemical and biochemical processes. NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. In general, ODNP uses microwave radiation to increase NMR detection sensitivity by up to two orders of magnitude. This combined instrument allows simultaneous detection of EPR and amplified NMR signals for the thorough characterization of the properties of molecular systems. This instrument enhances the educational, research, and teaching efforts of students at all levels in multiple departments at New York University as well as regional institutions in the surrounding area.The award of the EPR spectrometer is aimed at enhancing research and education at all levels, especially to investigate molecular mechanisms of proteins, cells, and inorganic samples. The instrument impacts research focused on studying optically generated spin polarization in chromophore radical systems, charge transport in twisted organic semiconductor crystals, and understanding impurity doping in semiconductor nanocrystals. It also assists in the in situ characterization of paramagnetic intermediates in nickel-catalyzed reactions. Other investigations include the determination of mechanisms of membrane protein transporters, structural characterization of protein and protein assemblies, and to detect conformational changes in disordered proteins. The instrument further impacts the study of radical species on block copolymers, nitrogen-vacancy centers in diamond for quantum information sensing and spin hyperpolarization, and optically generated spin polarization for magnetic resonance imaging. The research projects to be enabled by the instrument could lead to impacts in the fields of quantum science and energy storage.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器项目和化学研究仪器项目共同支持。纽约大学正在升级X波段电子顺磁共振(EPR)光谱仪的电子设备，包括配备Overhauser动态核极化(ODNP)核磁共振(NMR)检测的脉冲EPR，以支持Claudia Avalos教授及其同事Bart E.Kahr和Stephanie Lee的研究。该仪器促进了生物化学、生物物理学和材料科学领域的研究。该仪器结合了三种技术：电子顺磁共振(EPR)、核磁共振(核磁共振)和奥弗豪瑟动态核极化(ODNP)。EPR光谱仪提供有关分子和固态材料的几何和电子结构的详细信息。它还可以用来获取有关重要化学和生化过程中涉及的短寿命、高活性物种的寿命的信息。核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。通常，ODNP使用微波辐射将核磁共振检测灵敏度提高高达两个数量级。这种组合仪器允许同时检测EPR和放大的核磁共振信号，以彻底表征分子系统的性质。这台仪器加强了纽约大学多个系的各级学生以及周边地区机构的教育、研究和教学努力。EPR光谱仪的获奖旨在加强各级的研究和教育，特别是研究蛋白质、细胞和无机样品的分子机制。该仪器影响的研究重点是研究生色团自由基体系中的光学产生的自旋极化，扭曲的有机半导体晶体中的电荷传输，以及了解半导体纳米晶体中的杂质掺杂。它还有助于镍催化反应中顺磁性中间体的原位表征。其他研究包括确定膜蛋白转运蛋白的机制，蛋白质和蛋白质组合的结构特征，以及检测无序蛋白质的构象变化。该仪器进一步影响了嵌段共聚物上的自由基物种、用于量子信息传感和自旋超极化的钻石中的氮空位中心以及用于磁共振成像的光学产生的自旋极化的研究。该仪器支持的研究项目可能会在量子科学和能源存储领域产生影响。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。