Biophotonics: Biophotonic Sensors Based on Polymer Microspheres Evanescently Coupled to Optical Fiber

生物光子学:基于瞬逝耦合光纤的聚合物微球的生物光子传感器

基本信息

  • 批准号:
    0119273
  • 负责人:
  • 金额:
    $ 44.54万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-09-15 至 2005-08-31
  • 项目状态:
    已结题

项目摘要

0119273ArnoldThe applicant proposes to investigate photonic sensors based on dielectric microspheres evanescently coupled to optical fibers, and to develop microsphere sensors for biochemical and biological sensing. The unprecedentedly narrow optical resonances in such microspheres open an avenue for a novel class of all-optical sensors which can measure local properties by detecting optical frequency shifts of the resonances. Many photonic resonance modes occur in a microsphere in an extremely narrow linewidth. The resonance spectrum is obtained by scanning the wavelength of the laser transmitted through the fiber into the microsphere and observing the intensity through a read-out fiber coupled to the microsphere. Resonance wavelength shifts are extremely sensitive to changes in the diameter and the refractive index of the sphere as well as the refractive index of the medium surrounding the sphere. The latter quantities are determined by the temperature, adsorption of a second substance onto the sphere surface, the isotropic and anisotropic stress, and the concentration of a chemical in the solution surrounding the sphere. Efforts will be especially targeted at developing microscopic sensing heads for biofluids. For this purpose fibers and microspheres, all made of polymers that can be rendered biocompatible will be used. The high specificity in biomolecular interactions will enable detection of a specific RNA, protein, enzyme, substrate, and antigen. The goal is to allow one to prepare as many kinds of sensors as the number of biomolecules. Availability of miniature, high-sensitivity biophotonic sensors will facilitate the development of 'device on a chip' and other parallel chemical and biological analysis systems in combinatorial chemistry.
申请人建议研究基于逐渐耦合到光纤的介电微球的光子传感器,并开发用于生化和生物传感的微球传感器。这种微球中空前窄的光学共振为一类新型的全光传感器开辟了一条道路,这种传感器可以通过检测共振的光学频移来测量局部性质。在一个极窄的线宽内,微球中出现了许多光子共振模。共振光谱是通过扫描穿过光纤进入微球的激光的波长,并通过耦合到微球的读出光纤观察强度来获得的。共振波长漂移对球体的直径和折射率以及球体周围介质的折射率的变化极为敏感。后一个量由温度、第二种物质在球体表面的吸附、各向同性和各向异性应力以及围绕球体的溶液中化学物质的浓度决定。努力将特别针对开发用于生物流体的显微传感头。为此,将使用纤维和微球,这些纤维和微球都是由可以实现生物相容性的聚合物制成的。生物分子相互作用的高度特异性将使特定的RNA、蛋白质、酶、底物和抗原的检测成为可能。其目标是使人们能够制备与生物分子数量一样多的传感器。微型、高灵敏度生物光子学传感器的问世将促进组合化学中芯片设备和其他并行化学和生物分析系统的发展。

项目成果

期刊论文数量(0)
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Stephen Arnold其他文献

Evaluating modelled tropospheric columns of CH4, CO, and O3 in the Arctic using ground-based Fourier transform infrared (FTIR) measurements
使用地面傅里叶变换红外 (FTIR) 测量评估北极模拟对流层 CH4、CO 和 O3 柱
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    6.3
  • 作者:
    Victoria A. Flood;K. Strong;C. Whaley;Kaley A. Walker;T. Blumenstock;J. Hannigan;J. Mellqvist;J. Notholt;M. Palm;A. Röhling;Stephen Arnold;S. Beagley;R. Chien;Jesper Christensen;M. Deushi;S. Dobricic;Xinyi Dong;Joshua S. Fu;Michael Gauss;Wanmin Gong;J. Langner;Kathy S. Law;L. Marelle;T. Onishi;N. Oshima;David A. Plummer;Luca Pozzoli;J. Raut;M. Thomas;S. Tsyro;S. Turnock
  • 通讯作者:
    S. Turnock
Aerosol particle molecular spectroscopy.
气溶胶颗粒分子光谱。
  • DOI:
    10.1364/ao.24.001048
  • 发表时间:
    1985
  • 期刊:
  • 影响因子:
    1.9
  • 作者:
    Stephen Arnold;É. Murphy;G. Sageev
  • 通讯作者:
    G. Sageev
The graphics calculator in mathematics education: A critical review of recent research

Stephen Arnold的其他文献

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{{ truncateString('Stephen Arnold', 18)}}的其他基金

Whispering Gallery Mode Carousel: A means for Enhanced Detection in Biosensing and Surface-Force Probing
回音壁模式旋转木马:生物传感和表面力探测中增强检测的方法
  • 批准号:
    0933531
  • 财政年份:
    2009
  • 资助金额:
    $ 44.54万
  • 项目类别:
    Standard Grant
Biophotonics: Microsphere Whispering Gallery Mode Biosensor
生物光子学:微球回音壁模式生物传感器
  • 批准号:
    0522668
  • 财政年份:
    2005
  • 资助金额:
    $ 44.54万
  • 项目类别:
    Standard Grant
The Surface Spectroscopy of a Single Aerosol Particle
单个气溶胶颗粒的表面光谱
  • 批准号:
    8905871
  • 财政年份:
    1989
  • 资助金额:
    $ 44.54万
  • 项目类别:
    Continuing grant
A Microparticle as an Optical Memory
作为光学存储器的微粒
  • 批准号:
    8706824
  • 财政年份:
    1987
  • 资助金额:
    $ 44.54万
  • 项目类别:
    Standard Grant
Molecular Spectroscopy of a Single Reactive Aerosol Particle
单个反应气溶胶颗粒的分子光谱
  • 批准号:
    8413574
  • 财政年份:
    1984
  • 资助金额:
    $ 44.54万
  • 项目类别:
    Continuing grant
Radiometric Levitation and the Photothermal Spectroscopy of Single Aerosol Particles
单个气溶胶颗粒的辐射悬浮和光热光谱
  • 批准号:
    8208313
  • 财政年份:
    1982
  • 资助金额:
    $ 44.54万
  • 项目类别:
    Continuing grant
Particulate Characterization By Photophoretic Spectroscopy, Fluorescence and Rotophotophoretic Spectroscopy
通过光泳光谱、荧光和旋转光泳光谱进行颗粒表征
  • 批准号:
    8006580
  • 财政年份:
    1980
  • 资助金额:
    $ 44.54万
  • 项目类别:
    Standard Grant

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NSF/FDA SiR:黑素测定法作为生物光子设备种族差异临床评估定量工具的验证和标准化
  • 批准号:
    2326485
  • 财政年份:
    2023
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    $ 44.54万
  • 项目类别:
    Standard Grant
Biophotonic Spectroscopy Systems
生物光子光谱系统
  • 批准号:
    560154-2021
  • 财政年份:
    2022
  • 资助金额:
    $ 44.54万
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    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
The National Center for Interventional Biophotonic Technologies (NCIBT)
国家介入生物光子技术中心 (NCIBT)
  • 批准号:
    10744968
  • 财政年份:
    2022
  • 资助金额:
    $ 44.54万
  • 项目类别:
The National Center for Interventional Biophotonic Technologies (NCIBT)
国家介入生物光子技术中心 (NCIBT)
  • 批准号:
    10649445
  • 财政年份:
    2022
  • 资助金额:
    $ 44.54万
  • 项目类别:
The National Center for Interventional Biophotonic Technologies (NCIBT)
国家介入生物光子技术中心 (NCIBT)
  • 批准号:
    10424945
  • 财政年份:
    2022
  • 资助金额:
    $ 44.54万
  • 项目类别:
Biophotonic Spectroscopy Systems
生物光子光谱系统
  • 批准号:
    560154-2021
  • 财政年份:
    2021
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    $ 44.54万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
STTR Phase I: Biophotonic plant foliage optical inspection system for improved indoor molecular farming of plant-based medicines
STTR 第一阶段:生物光子植物叶子光学检测系统,用于改进植物药物的室内分子农业
  • 批准号:
    2111730
  • 财政年份:
    2021
  • 资助金额:
    $ 44.54万
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Biophotonic Spectroscopy Systems
生物光子光谱系统
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    560154-2021
  • 财政年份:
    2021
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    $ 44.54万
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    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Developing a non-contact biophotonic imaging system for monitoring cardiovascular reflex and hemodynamics in older adults'**naturalistic environments
开发非接触式生物光子成像系统,用于监测老年人**自然环境中的心血管反射和血流动力学
  • 批准号:
    503038-2017
  • 财政年份:
    2018
  • 资助金额:
    $ 44.54万
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    Postdoctoral Fellowships
Advanced biophotonic materials: developing a toolkit for quantum dot-membrane-protein nanocomposites
先进生物光子材料:开发量子点-膜-蛋白质纳米复合材料工具包
  • 批准号:
    2131269
  • 财政年份:
    2018
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  • 项目类别:
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