The National Center for Interventional Biophotonic Technologies (NCIBT)

国家介入生物光子技术中心 (NCIBT)

• 批准号: 10744968
• 负责人: Griffith R. Harsh
• 金额: $ 6.74万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-20 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744968
• 关键词: Acceleration; Acute; Address; Algorithms; Area; Biophotonics; Cardiology; Cerebrovascular Circulation; Clinical; Clinical Management; Cognition; Collaborations; Communities; Complement; Data; Decision Making; Degenerative Disorder; Dementia; Development; Diagnosis; Diffuse; Diffusion; Disease Management; Educational workshop; Electronic Mail; Engineering; Ensure; Equipment; Fetal health; General Population; Goals; Hand; Health; Heart Diseases; High-Risk Pregnancy; Human; Humanities; Image; Imaging Device; Imaging Techniques; Imaging technology; Immersion; Individual; Infection; Institution; Intelligence; Intervention; Legal patent; Link; Literature; Malignant Neoplasms; Medical; Medical Societies; Medical center; Medicine; Metabolism; Monitor; Near-Infrared Spectroscopy; Ophthalmology; Optics; Participant; Patient-Focused Outcomes; Patients; Perfusion; Physicians; Procedures; Program Development; Property; Public Health; Publications; Research; Research Project Grants; Resolution; Schools; Scientist; Services; Source; Spectrum Analysis; Speed; Stroke; Structure; Surgeon; Surgical Oncologist; Surgical Oncology; System; Technology; Therapeutic; Time; Tissues; Training; Training Programs; Translations; Trauma; Traumatic Shock; Vision; Visit; Visualization; Work; analytical tool; clinical application; clinical decision-making; clinical translation; commercialization; computerized tools; data streams; deep learning; design; fluorescence lifetime imaging; global health; holistic approach; image guided; imaging modality; imaging platform; improved; individualized medicine; industry partner; innovation; instrument; interest; meetings; nervous system disorder; novel; open source; optical imaging; photonics; precision medicine; program dissemination; programs; residence; social media; symposium; technology development; technology training; tumor; web site

PROJECT SUMMARY – Overall The long-term goal of the National Center for Interventional Biophotonic Technologies (NCIBT) is to promote public health by advancing a new paradigm for intraprocedural, image-guided decision making. The Center's strategy is to advance optical spectroscopy and imaging technologies, to develop means of providing imaging results to medical practitioners at the time, in the form, and within the context they will be most useful in guiding decisions, and to maximize the impact of this work by involving as many scientists and physicians as possible in developing and using these technologies. Initially, the Center will promote technological advancements of interventional fluorescence lifetime imaging (iFLIM) and interferometric diffuse optical spectroscopy (iDOS) and their translation into clinical use. An open-ended intraprocedural platform will incorporate them and, eventually, complementary optical imaging technologies. Specifically, NCIBT will (1) advance scalable optical imaging technology, built from the perspective of intelligent optical system design, to characterize tissue properties in the most effective manner; (2) develop an intraprocedural platform that physically incorporates these technologies and integrates the resulting imaging data, details of the procedure, and patient-specific information within AI- based decision algorithms that guide, in real-time, therapeutic decisions, and (3) disseminate these technological advancements to research institutions and medical centers. The significance of this project derives from its potential for rapid advancement, catalyzed by an AI-directed holistic approach to instrument design, of its optical imaging technologies and platform and their relevance to managing humanity's most common afflictions - cancer, stroke, heart disease, trauma, infection, and degenerative diseases. NCIBT will ensure the national impact of these technological advancements by creating and expanding a network of collaborative research and service projects broadly distributed nationwide and implementing a comprehensive training and dissemination program. Annual workshops, hand-on training sessions at national meetings, in special courses and at UC Davis, presentations and publications will educate, train, equip and diversify potential users of NCIBT technology. Bridging gaps between engineering and medicine and between technology development and clinical application will ensure that the needed technologies are developed and applied clinically to improve the nation's health.

项目概要-总体 国家介入生物光子技术中心（NCIBT）的长期目标是促进 通过推进程序内图像引导决策的新范式，为公共卫生服务。该中心的 战略是推进光学光谱学和成像技术，发展提供成像的手段， 结果，医生在当时，在形式上，并在上下文中，他们将是最有用的指导 决策，并通过让尽可能多的科学家和医生参与进来， 开发和使用这些技术。该中心最初将促进技术进步， 介入荧光寿命成像（iFLIM）和干涉漫射光谱（iDOS）， 转化为临床应用。一个不限成员名额的程序内平台将纳入这些建议， 互补光学成像技术。具体而言，NCIBT将（1）推进可扩展的光学成像 技术，从智能光学系统设计的角度构建，以表征 最有效的方式;（2）开发一个实际上包含这些技术的程序内平台 并将所得成像数据、手术细节和患者特定信息整合到AI中， 基于决策算法，实时指导治疗决策，以及（3）传播这些技术 研究机构和医疗中心的进步。该项目的意义在于其 在人工智能指导的仪器设计整体方法的催化下， 成像技术和平台及其与管理人类最常见的疾病-癌症， 中风、心脏病、创伤、感染和退行性疾病。NCIBT将确保国家的影响， 通过创建和扩大合作研究和服务网络， 项目在全国范围内广泛分布，并实施全面的培训和宣传方案。 年度研讨会，在国家会议上的实践培训课程，在特别课程和加州大学戴维斯分校， 演讲和出版物将教育、培训、装备NCIBT技术的潜在用户并使其多样化。 弥合工程与医学、技术开发与临床应用之间的差距 将确保所需的技术得到开发和临床应用，以改善国民健康。

项目成果

Virtual tissue staining in pathology using machine learning

使用机器学习进行病理学虚拟组织染色

• DOI: 10.1080/14737159.2022.2153040
• 发表时间: 2022
• 期刊: Expert Review of Molecular Diagnostics
• 影响因子: 5.1
• 作者: Pillar, Nir;Ozcan, Aydogan
• 通讯作者: Ozcan, Aydogan