The National Center for Interventional Biophotonic Technologies (NCIBT)

国家介入生物光子技术中心 (NCIBT)

• 批准号: 10744968
• 负责人: Griffith R. Harsh
• 金额: $ 6.74万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-20 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744968
• 关键词: Acceleration; Acute; Address; Algorithms; Area; Biophotonics; Cardiology; Cerebrovascular Circulation; Clinical; Clinical Management; Cognition; Collaborations; Communities; Complement; Data; Decision Making; Degenerative Disorder; Dementia; Development; Diagnosis; Diffuse; Diffusion; Disease Management; Educational workshop; Electronic Mail; Engineering; Ensure; Equipment; Fetal health; General Population; Goals; Hand; Health; Heart Diseases; High-Risk Pregnancy; Human; Humanities; Image; Imaging Device; Imaging Techniques; Imaging technology; Immersion; Individual; Infection; Institution; Intelligence; Intervention; Legal patent; Link; Literature; Malignant Neoplasms; Medical; Medical Societies; Medical center; Medicine; Metabolism; Monitor; Near-Infrared Spectroscopy; Ophthalmology; Optics; Participant; Patient-Focused Outcomes; Patients; Perfusion; Physicians; Procedures; Program Development; Property; Public Health; Publications; Research; Research Project Grants; Resolution; Schools; Scientist; Services; Source; Spectrum Analysis; Speed; Stroke; Structure; Surgeon; Surgical Oncologist; Surgical Oncology; System; Technology; Therapeutic; Time; Tissues; Training; Training Programs; Translations; Trauma; Traumatic Shock; Vision; Visit; Visualization; Work; analytical tool; clinical application; clinical decision-making; clinical translation; commercialization; computerized tools; data streams; deep learning; design; fluorescence lifetime imaging; global health; holistic approach; image guided; imaging modality; imaging platform; improved; individualized medicine; industry partner; innovation; instrument; interest; meetings; nervous system disorder; novel; open source; optical imaging; photonics; precision medicine; program dissemination; programs; residence; social media; symposium; technology development; technology training; tumor; web site

PROJECT SUMMARY – Overall The long-term goal of the National Center for Interventional Biophotonic Technologies (NCIBT) is to promote public health by advancing a new paradigm for intraprocedural, image-guided decision making. The Center's strategy is to advance optical spectroscopy and imaging technologies, to develop means of providing imaging results to medical practitioners at the time, in the form, and within the context they will be most useful in guiding decisions, and to maximize the impact of this work by involving as many scientists and physicians as possible in developing and using these technologies. Initially, the Center will promote technological advancements of interventional fluorescence lifetime imaging (iFLIM) and interferometric diffuse optical spectroscopy (iDOS) and their translation into clinical use. An open-ended intraprocedural platform will incorporate them and, eventually, complementary optical imaging technologies. Specifically, NCIBT will (1) advance scalable optical imaging technology, built from the perspective of intelligent optical system design, to characterize tissue properties in the most effective manner; (2) develop an intraprocedural platform that physically incorporates these technologies and integrates the resulting imaging data, details of the procedure, and patient-specific information within AI- based decision algorithms that guide, in real-time, therapeutic decisions, and (3) disseminate these technological advancements to research institutions and medical centers. The significance of this project derives from its potential for rapid advancement, catalyzed by an AI-directed holistic approach to instrument design, of its optical imaging technologies and platform and their relevance to managing humanity's most common afflictions - cancer, stroke, heart disease, trauma, infection, and degenerative diseases. NCIBT will ensure the national impact of these technological advancements by creating and expanding a network of collaborative research and service projects broadly distributed nationwide and implementing a comprehensive training and dissemination program. Annual workshops, hand-on training sessions at national meetings, in special courses and at UC Davis, presentations and publications will educate, train, equip and diversify potential users of NCIBT technology. Bridging gaps between engineering and medicine and between technology development and clinical application will ensure that the needed technologies are developed and applied clinically to improve the nation's health.

项目概要——总体 国家介入生物光子技术中心（NCIBT）的长期目标是促进 通过推进程序内图像引导决策的新范式来促进公共卫生。该中心的 战略是推进光谱学和成像技术，开发提供成像的手段 结果以当时的形式和背景向医生提供，它们对于指导是最有用的 决策，并通过让尽可能多的科学家和医生参与来最大限度地发挥这项工作的影响 开发和使用这些技术。首先，该中心将促进技术进步 介入荧光寿命成像 (iFLIM) 和干涉漫反射光谱 (iDOS) 以及 将其转化为临床应用。一个开放式的程序内平台将整合它们，并最终， 互补光学成像技术。具体来说，NCIBT 将 (1) 推进可扩展光学成像 技术，从智能光学系统设计的角度构建，以表征组织特性 最有效的方式； (2) 开发一个物理上整合这些技术的程序内平台 并将生成的成像数据、手术细节和患者特定信息集成到人工智能中 基于决策算法，实时指导治疗决策，以及（3）传播这些技术 研究机构和医疗中心的进步。该项目的意义在于 在人工智能引导的整体仪器设计方法的催化下，其光学技术具有快速发展的潜力 成像技术和平台及其与管理人类最常见疾病 - 癌症、 中风、心脏病、创伤、感染和退行性疾病。 NCIBT 将确保其全国影响力 通过创建和扩展协作研究和服务网络来实现这些技术进步 项目广泛分布于全国并实施全面的培训和传播计划。 年度研讨会、国家会议、特别课程和加州大学戴维斯分校的实践培训课程， 演示文稿和出版物将对 NCIBT 技术的潜在用户进行教育、培训、装备和多样化。 弥合工程与医学之间以及技术开发与临床应用之间的差距 将确保所需技术的开发和临床应用，以改善国民的健康。

项目成果

Virtual tissue staining in pathology using machine learning

使用机器学习进行病理学虚拟组织染色

• DOI: 10.1080/14737159.2022.2153040
• 发表时间: 2022
• 期刊: Expert Review of Molecular Diagnostics
• 影响因子: 5.1
• 作者: Pillar, Nir;Ozcan, Aydogan
• 通讯作者: Ozcan, Aydogan