Whispering Gallery Mode Carousel: A means for Enhanced Detection in Biosensing and Surface-Force Probing

回音壁模式旋转木马:生物传感和表面力探测中增强检测的方法

基本信息

  • 批准号:
    0933531
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-09-15 至 2013-08-31
  • 项目状态:
    已结题

项目摘要

0933531ArnoldVirus particles are a major cause for human disease, and their early detection and identification is of increasing importance as air travel allows these infectious agents to spread rapidly to populations across the globe. A fast detector that is sensitive to a single virus particle by determining its genus and size would answer the demand for early detection. The present proposal is to continues the investigation into microsphere whispering gallery mode (WGM) biosensors for early detection of viruses in human fluids as we utilize a recently discovered phenomenon of light trapping of nanoparticles within the WGM evanescent volume. The sensing is based on the extremely narrow photonic resonances of microspheres that shift their frequencies as a result of an environmental change. Within the reach of the WGM?s evanescent field (~ 200 nm) nanoparticles are drawn toward the surface by gradient forces, similar to those present in optical tweezers. A trapping potential-well is formed by an attractive evanescent polarization potential, repulsive electrostatic potential, and van der Waals potential. In the case of a low binding-affinity or a low density of binding sites, nanoparticles are propelled around in orbit by radiation pressure. This trapping mechanism (WGM Carousel) along with controlled binding-affinity adds additional functionality and assures high sensitivity and specificity to the WGM biosensor. The ultimate goal is to build microfluidic biosensors that are sensitive to a single viral particle and can differentiate virions according to their size/mass and affinity to specific antibodies. The small size of these bio-particles demands micrometer-size sensors3. However Brownian diffusion of ultra-low concentration analytes crossing the boundary layer is considered a major hurdle4 for miniature sensors. Preliminary results show that the WGM Carousel sensor can have significantly enhanced transport rates ( 50×) of particles to the sensing region, compared to other miniature sensors. In addition the carousel mechanism provides a means for investigating forces arising near the surface. Understanding these forces is of great importance for the design of microfluidic devices and micro-fabrication. Nanoparticles trapped in a WGM carousel can be used to quantitatively measure surface interactions from their stochastic radial motion. By proper choice of the interacting surfaces and the liquid medium it will be possible to screen the electrostatic repulsion and reveal short range interactions such as van der Waals. There are challenges for the DLVO (the theory of colloidal stability) to properly describe the interactions at very short range (5nm) for various aqueous solutions, where repulsive solvation forces are observed. WGM Carousel will help address these challenges.
ArnoldVirus粒子是人类疾病的主要原因,随着航空旅行使这些传染病病原体迅速传播到全球各地的人群中,它们的早期检测和识别变得越来越重要。一种通过确定单个病毒颗粒的种类和大小来对其敏感的快速检测器将满足早期检测的需求。目前的建议是继续研究微球耳廊模式(WGM)生物传感器,以早期检测人体体液中的病毒,因为我们利用最近发现的WGM消逝体积内纳米颗粒的光捕获现象。这种传感是基于微球的极窄光子共振,这些微球的频率会因环境变化而发生变化。在WGM?S逝去场(~200 nm)的范围内,纳米粒子被梯度力吸引到表面,类似于光镊子中的情况。俘获势垒是由吸引的消逝极化势、排斥静电势和范德华势能形成的。在低结合亲和力或低结合部位密度的情况下,纳米颗粒在辐射压力的推动下在轨道上四处移动。这种捕获机制(WGM Carousel)与受控的结合亲和力一起增加了额外的功能,并确保了WGM生物传感器的高灵敏度和特异性。最终目标是建立对单个病毒颗粒敏感的微流控生物传感器,并可以根据病毒粒子的大小/质量和对特定抗体的亲和力来区分病毒粒子。这些生物颗粒的小尺寸需要微米级的传感器。然而,超低浓度分析物跨越边界层的布朗扩散被认为是微型传感器的一个主要障碍。初步结果表明,与其他微型传感器相比,WGM Carousel传感器可以显著提高颗粒到传感区域的传输率(50倍)。此外,旋转木马机制提供了一种调查在地表附近产生的力的方法。了解这些力对于微流控器件的设计和微细加工具有重要意义。捕获在WGM旋转木马中的纳米颗粒可以用来根据其随机的径向运动来定量测量表面相互作用。通过适当选择相互作用面和液体介质,可以屏蔽静电斥力,揭示短程相互作用,如范德华作用。对于DLVO(胶体稳定性理论)来说,要恰当地描述在很短的范围(5 Nm)内观察到排斥溶剂化力的各种水溶液的相互作用是很困难的。WGM Carousel将帮助应对这些挑战。

项目成果

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Stephen Arnold其他文献

Evaluating modelled tropospheric columns of CH4, CO, and O3 in the Arctic using ground-based Fourier transform infrared (FTIR) measurements
使用地面傅里叶变换红外 (FTIR) 测量评估北极模拟对流层 CH4、CO 和 O3 柱
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    6.3
  • 作者:
    Victoria A. Flood;K. Strong;C. Whaley;Kaley A. Walker;T. Blumenstock;J. Hannigan;J. Mellqvist;J. Notholt;M. Palm;A. Röhling;Stephen Arnold;S. Beagley;R. Chien;Jesper Christensen;M. Deushi;S. Dobricic;Xinyi Dong;Joshua S. Fu;Michael Gauss;Wanmin Gong;J. Langner;Kathy S. Law;L. Marelle;T. Onishi;N. Oshima;David A. Plummer;Luca Pozzoli;J. Raut;M. Thomas;S. Tsyro;S. Turnock
  • 通讯作者:
    S. Turnock
Aerosol particle molecular spectroscopy.
气溶胶颗粒分子光谱。
  • DOI:
    10.1364/ao.24.001048
  • 发表时间:
    1985
  • 期刊:
  • 影响因子:
    1.9
  • 作者:
    Stephen Arnold;É. Murphy;G. Sageev
  • 通讯作者:
    G. Sageev
The graphics calculator in mathematics education: A critical review of recent research

Stephen Arnold的其他文献

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{{ truncateString('Stephen Arnold', 18)}}的其他基金

Biophotonics: Microsphere Whispering Gallery Mode Biosensor
生物光子学:微球回音壁模式生物传感器
  • 批准号:
    0522668
  • 财政年份:
    2005
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Biophotonics: Biophotonic Sensors Based on Polymer Microspheres Evanescently Coupled to Optical Fiber
生物光子学:基于瞬逝耦合光纤的聚合物微球的生物光子传感器
  • 批准号:
    0119273
  • 财政年份:
    2001
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
The Surface Spectroscopy of a Single Aerosol Particle
单个气溶胶颗粒的表面光谱
  • 批准号:
    8905871
  • 财政年份:
    1989
  • 资助金额:
    --
  • 项目类别:
    Continuing grant
A Microparticle as an Optical Memory
作为光学存储器的微粒
  • 批准号:
    8706824
  • 财政年份:
    1987
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Molecular Spectroscopy of a Single Reactive Aerosol Particle
单个反应气溶胶颗粒的分子光谱
  • 批准号:
    8413574
  • 财政年份:
    1984
  • 资助金额:
    --
  • 项目类别:
    Continuing grant
Radiometric Levitation and the Photothermal Spectroscopy of Single Aerosol Particles
单个气溶胶颗粒的辐射悬浮和光热光谱
  • 批准号:
    8208313
  • 财政年份:
    1982
  • 资助金额:
    --
  • 项目类别:
    Continuing grant
Particulate Characterization By Photophoretic Spectroscopy, Fluorescence and Rotophotophoretic Spectroscopy
通过光泳光谱、荧光和旋转光泳光谱进行颗粒表征
  • 批准号:
    8006580
  • 财政年份:
    1980
  • 资助金额:
    --
  • 项目类别:
    Standard Grant

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テラヘルツ帯whispering gallery mode共鳴分光法の開発
太赫兹波段回音壁模式共振光谱学的发展
  • 批准号:
    24KJ1678
  • 财政年份:
    2024
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Exploring the spin-orbit interaction of light in the whispering gallery mode hollow-microcavities
探索回音壁模式中空微腔中光的自旋轨道相互作用
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    24K08290
  • 财政年份:
    2024
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Fiber-integrated diamond-based whispering-gallery-mode magnetometers
光纤集成金刚石基回音壁模式磁力计
  • 批准号:
    23K04617
  • 财政年份:
    2023
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    --
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    Grant-in-Aid for Scientific Research (C)
Analysis of spectral shapes with narrow linewidths of high-Q organic crystal whispering gallery mode cavities
高Q值有机晶体回音壁模式腔窄线宽光谱形状分析
  • 批准号:
    20K04577
  • 财政年份:
    2020
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    --
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    Grant-in-Aid for Scientific Research (C)
Whispering Gallery Mode Devices for the Rapid Detection of Pan-Filoviruses
用于快速检测泛丝状病毒的回音壁模式装置
  • 批准号:
    10081794
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Whispering Gallery Mode Devices for the Rapid Detection of Pan-Filoviruses
用于快速检测泛丝状病毒的回音壁模式装置
  • 批准号:
    10211125
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Whispering gallery mode microcavities for photonic sensing applications
用于光子传感应用的回音壁模式微腔
  • 批准号:
    RGPIN-2015-05808
  • 财政年份:
    2019
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    --
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    Discovery Grants Program - Individual
electro driven whispering gallery mode optical resonator from self-assembled conjugated polymer microspheres
自组装共轭聚合物微球电驱动回音壁模式光学谐振器
  • 批准号:
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  • 财政年份:
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    --
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Whispering gallery mode microcavities for photonic sensing applications
用于光子传感应用的回音壁模式微腔
  • 批准号:
    RGPIN-2015-05808
  • 财政年份:
    2018
  • 资助金额:
    --
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    Discovery Grants Program - Individual
Electrowetting-Tuned Liquid Droplets on Lubricated Superhydrophobic Surfaces for Whispering-Gallery-Mode Sensing
用于耳语画廊模式传感的润滑超疏水表面上的电润湿调谐液滴
  • 批准号:
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