Biophotonics: Spectroscopy of Picoliter Fluid Volumes for Biological and Chemical Analysis

生物光子学：用于生物和化学分析的皮升流体体积的光谱学

• 批准号: 0119493
• 负责人: Axel Scherer
• 金额: $ 50.01万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0119493&HistoricalAwards=false
• 关键词: Biophotonics; Spectroscopy; Picoliter; Fluid; Volumes

0119493SchererThe objective of the proposed research is to develop and build compact absorption spectrometers and fluorescence measurement systems with the capability to test and identify the composition of picoliters of analyte. The approach is to integrate microfabrication techniques for both microfluidic and photonic devices in order to create monolithic analysis "chips" for bio-analysis applications. Specifically, three optical technologies will be developed and integrated into microfluidic systems: (1) Fabry-Perot optical resonators with high-finesse for optical spectroscopy, (2) photonic crystal nanocavities for interferometric sensing with high sensitivity, and (3) development of manufacturable solid immersion lenses for high numerical aperture examination of microfluidic samples.

[01:19 . 93] scherer本研究的目的是开发和建立紧凑的吸收光谱仪和荧光测量系统，以测试和识别皮升分析物的组成。该方法是集成微流体和光子器件的微制造技术，以创建用于生物分析应用的单片分析“芯片”。具体而言，将开发三种光学技术并将其集成到微流控系统中：(1)用于光学光谱的高精细度法布里-珀罗光学谐振器，(2)用于高灵敏度干涉传感的光子晶体纳米腔，以及(3)用于微流控样品高数值孔径检测的可制造固体浸没透镜。