2001 Technology for a Sustainable Environment: High Activity Catalysts for Carbon-Carbon Bond Formation in Water Based on Bulky Water-Soluble Alkylphosphines (TSE01-A)

本研究的重点是开发用于合成有用反应的高活性催化剂，如Heck，Suzuki和Buchwald-Hartwig偶联。为此，水溶性的烷基膦将被合成并与水相钯催化的偶联反应结合使用。 这些反应有效地提供了从药物和农业化学品到电子材料和商品化学品等领域的感兴趣的结构。通过这一新的NSF/EPA可持续环境技术（TSE）奖，有机和高分子化学计划以及数学和物理科学理事会多学科活动办公室正在支持Kevin H.位于塔斯卡卢萨的亚拉巴马大学化学系的肖内西说。 Shaughnessy教授将把他的研究重点放在开发一种新的空间要求，水溶性烷基膦在钯催化的C-C和C-杂原子键形成反应中使用环境友好的水溶剂的方法。工业界采用这一方法可减少危险废物的产生、减少能源消耗和减少挥发性有机溶剂的使用。 从事该项目的本科生，研究生和博士后学生将获得有机和有机金属化学的基础教育以及开发环境友好化学反应的方法。

The focus of this research is the development of highly reactive catalysts for synthetically useful reactions such as the Heck, Suzuki and Buchwald-Hartwig couplings. To this end, water-soluble alkylphosphines will be synthesized and used in conjunction with aqueous-phase palladium-catalyzed coupling reactions. These reactions efficiently provide structures of interest in areas ranging from pharmaceuticals and agricultural chemicals to electronic materials and commodity chemicals.With this new NSF/EPA Technology for a Sustainable Environment (TSE) award, the Organic and Macromolecular Chemistry Program and the Office of Multidisciplinary Activities of the Directorate of Mathematics and Physical Sciences are supporting the research efforts of Dr. Kevin H. Shaughnessy of the Department of Chemistry at the University of Alabama, Tuscaloosa. Professor Shaughnessy will focus his research on developing methodology for the use of a new class of sterically demanding, water-soluble alkylphosphines in palladium-catalyzed C-C and C-heteroatom bond forming reactions using environmentally benign aqueous solvent. Adoption of this methodology by industry could result in the decrease of hazardous waste generation, decrease in energy consumption and decrease in the use of volatile organic solvents. The undergraduate, graduate and post-doctoral students working on this project will gain a fundamental education in organic and organometallic chemistry and approaches to developing environmentally benign chemical reactions.