2001 Technology for a Sustainable Environment: NSF/EPA Partnership: Metabolic Engineering of Monooxygenases for 1-Naphthol and Styrene Epoxide Formation (TSE01-D)
2001 Technology for a Sustainable Environment: NSF/EPA Partnership: Metabolic Engineering of Monooxygenases for 1-Naphthol and Styrene Epoxide Formation (TSE01-D)
批准号:
0611950
负责人:
Thomas Wood
金额:
$8.14万
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-10-15 至 2006-02-28
中文摘要
0124401Wood这个项目的目标是优化单加氧酶的活性和表达,以将萘转化为1-萘酚和(手性)环氧苯乙烷。用所提议的酶替代法替代目前生产1-萘酚和环氧苯乙烷的方法可能被证明是更环保的,因为将产生更少的溶剂和副产品废物。这项工作有两个组成部分:(1)酶“育种”(康涅狄格大学)和(2)表达调控和生物过程优化(马里兰大学),它们是高度协同的。
英文摘要
0124401WoodThe objective of this project is to optimize the activity and expression of monooxygenases for the purpose of converting naphthalene to 1-naphthol and (chiral) styrene epoxide. Replacing the current method for producing 1-naphthol and styrene epoxide with the proposed enzymatic alternative may prove to be more environmentally benign in that less solvent and by-product wastes will result. There are two components to the work: (1) enzyme "breeding" (University of Connecticut) and (2) regulation of expression and bioprocess optimization (University of Maryland), which are highly synergistic.
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依托单位:
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依托单位:
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批准号:1212320
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项目类别:Standard Grant
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资助金额:$5.99万
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Collaborative Research: A Systems Biology Approach for Metabolically Engineering Escherichia coli for Producing Hydrogen via Fermentation
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批准号:0753702
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资助金额:$15.0万
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Collaborative Research: Mating Signals and Demographic Divergence: Species Comparisons and Experimental Tests
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批准号:0132502
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项目类别:Standard Grant
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资助金额:$4.01万
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财政年份:2002
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负责人:Thomas Wood
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依托单位:
2001 Technology for a Sustainable Environment: NSF/EPA Partnership: Metabolic Engineering of Monooxygenases for 1-Naphthol and Styrene Epoxide Formation (TSE01-D)
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批准号:0124401
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项目类别:Continuing Grant
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资助金额:$69.01万
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财政年份:2002
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负责人:Thomas Wood
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依托单位:
Directed Evolution of Aromatic Dioxygenases for Trinitrotoluene and Aminodinitrotoluene Degradation
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批准号:0114126
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项目类别:Continuing Grant
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资助金额:$60.0万
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财政年份:2001
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负责人:Thomas Wood
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依托单位:
ME: Redirecting Cellular Metabolism for the Biodegradation of Mixtures of Chlorinated Solvents
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批准号:9911469
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项目类别:Continuing Grant
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资助金额:$34.8万
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财政年份:2000
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负责人:Thomas Wood
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依托单位:
SGER: Novel Antimicrobial and Antiviral Properties of the Hok Killer Protein
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批准号:9896369
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项目类别:Standard Grant
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资助金额:$1.6万
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财政年份:1998
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负责人:Thomas Wood
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依托单位:
Directed Evolution of Monooxygenases for Green Chemistry, Methanol Production, and Rhizoremediation
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批准号:9807146
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项目类别:Continuing Grant
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资助金额:$22.36万
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财政年份:1998
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负责人:Thomas Wood
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依托单位:
Host Plant Phenology and Insect Speciation
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批准号:9509125
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项目类别:Standard Grant
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资助金额:$8.91万
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财政年份:1996
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依托单位:
SGER: Novel Antimicrobial and Antiviral Properties of the Hok Killer Protein
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批准号:9615938
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项目类别:Standard Grant
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资助金额:$5.0万
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财政年份:1996
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负责人:Thomas Wood
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依托单位:
Enhanced Plasmid Stability Using Multiple Killer Genes
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批准号:9224864
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项目类别:Standard Grant
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资助金额:$4.73万
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财政年份:1993
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负责人:Thomas Wood
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依托单位:
Enhanced Bioremediation Using Genetically-Engineered Microbes
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批准号:9210619
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项目类别:Continuing Grant
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资助金额:$10.91万
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财政年份:1992
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负责人:Thomas Wood
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依托单位:
Collaborative Research: Insect Speciation Promoted by Host Plant Interaction
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批准号:8400245
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项目类别:Continuing Grant
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资助金额:$14.99万
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财政年份:1984
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负责人:Thomas Wood
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依托单位:
国内基金
海外基金
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