Acquisition of an integrated scanning probe, scanning laser, optical microscope

购置集成扫描探头、扫描激光、光学显微镜

• 批准号: 0132433
• 负责人: Steven Lower
• 金额: $ 34.99万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2004-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0132433&HistoricalAwards=false
• 关键词: Acquisition; integrated; scanning; probe; laser

0132433LowerThis grant provides partial support for a state-of-the-art instrument that integrates optical micros-copy, confocal laser scanning microscopy, scanning probe microscopy, and optical tweezers. It will be housed in the P.I.'s laboratory at the University of Maryland, where it will be a primary tool for the P.I.'s research programs in geomicrobiology, biogeochemistry, and nanoscale sci-ence. This instrument will be capable of collecting force measurements concurrent with optical observations as well as fluorescence resonance energy transfer. Further, it will allow the simul-taneous collection of atomic force microscopy (or scanning near-field optical microscopy) and laser scanning microscopy images. The applications of this instrument include for example: the study of fundamental intra- and inter-molecular forces between biomolecules on living cells and material surfaces (or other cells); identification of cell wall biomolecules which interact specifi-cally with particular minerals or cells; the study of the properties and localization of biomolecu-les on microbial surfaces; the study of mineral dissolution and growth including biomineraliza-tion; investigations of metal (or organic acid) sorption to mineral surfaces; the development of nanolithography techniques; and educational outreach.***

0132433LowerThis grant provides partial support for a state of-the-art instrument that integrates optical microscopy，coagulate laser scanning microscopy，scanning probe microscopy，and optical tweezers. 它将被安置在P.I.在马里兰州大学的实验室，它将成为PI的主要工具。的研究项目包括地球微生物学、地球化学和纳米科学。 该仪器将能够收集力的测量值，同时进行光学观测以及荧光共振能量转移。 此外，它将允许同时收集原子力显微镜（或扫描近场光学显微镜）和激光扫描显微镜图像。 该仪器的应用包括例如：活细胞和材料表面上的生物分子之间的基本分子内和分子间力的研究（或其他细胞）;鉴定与特定矿物或细胞特异性相互作用的细胞壁生物分子;研究生物分子在微生物表面的性质和定位;研究矿物溶解和生长，包括生物矿化;金属（或有机酸）吸附矿物表面的调查;纳米光刻技术的发展;以及教育推广。