MRI: Acquisition of integrated laser scanning/spinning disk confocal microscopy system to advance multidisciplinary research and training at Mount Holyoke College

MRI：采购集成激光扫描/旋转盘共焦显微镜系统，以推进曼荷莲学院的多学科研究和培训

• 批准号: 1827945
• 负责人: Kenneth Colodner
• 金额: $ 51.62万
• 依托单位: Mount Holyoke College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1827945&HistoricalAwards=false
• 关键词: MRI; Acquisition; integrated; laser; scanning

An award is made to Mount Holyoke College to acquire an integrated laser scanning/spinning disk confocal microscopy system that will enhance the diverse research and teaching needs of its faculty. This equipment will considerably strengthen STEM education at the oldest women's college in the country by promoting new and innovative microscopy-associated course offerings across the Life and Physical Science curriculum. Students will be afforded hands-on training with the most current and powerful instrumentation to both prepare them for the job market and enhance their candidacy for graduate-level education. The microscope will also be used as the focus of campus wide events specifically geared towards increasing representation of students of color in STEM fields.The confocal microscope will transform scientific inquiry of Mount Holyoke faculty spanning a variety of disciplines, organisms, model systems and preparations. The number of undergraduate-driven research activities in biology, neuroscience, chemistry, psychology, and physics will be increased by expanding opportunities for senior thesis research and summer internship projects ranging from fine-scale interrogations of cellular interactions to particle fluid dynamics and intracellular signaling pathways. The versatility of this microscopy system will transform the research and teaching platforms across STEM disciplines at Mount Holyoke College and provide new opportunities that prepare a diverse student body to work in cutting-edge research fields.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

一个奖项是作出了霍利奥克山学院获得一个集成的激光扫描/旋转盘共聚焦显微镜系统，将提高其教师的多样化的研究和教学需求。这些设备将大大加强在全国最古老的女子学院的STEM教育，通过促进新的和创新的显微镜相关课程提供整个生命和物理科学课程。学生将获得最新和最强大的仪器，以准备他们的就业市场，并提高他们的研究生水平教育的候选人动手培训。该显微镜也将被用作校园范围内的活动，特别是针对增加学生的颜色在STEM领域的代表性的焦点。共聚焦显微镜将改变跨越各种学科，生物，模型系统和准备的霍利奥克山教师的科学探究。生物学，神经科学，化学，心理学和物理学的本科生驱动的研究活动的数量将通过扩大高级论文研究和暑期实习项目的机会来增加，从细胞相互作用的精细尺度询问到粒子流体动力学和细胞内信号通路。该显微镜系统的多功能性将改变霍利奥克山学院STEM学科的研究和教学平台，并提供新的机会，为多元化的学生群体在前沿研究领域工作做好准备。该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估来支持。

项目成果

Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formation

• DOI: 10.1371/journal.pone.0226380
• 发表时间: 2019-12
• 期刊: PLoS ONE
• 影响因子: 3.7
• 作者: Enrico M Scarpelli;V. Y. Trinh;Zarrin Tashnim;J. Krans;Lani C Keller;Kenneth J. Colodner

Survival of Polyploid hybrid salamander embryos

• DOI: 10.1186/s12861-019-0202-z
• 发表时间: 2019-11-12
• 期刊: BMC DEVELOPMENTAL BIOLOGY
• 作者: Charney, Noah D.;Kubel, Jacob E.;Malone, John H.
• 通讯作者: Malone, John H.