CAREER: New Ligand Templates for Asymmetric Catalysis

本研究的重点是开发一种通用的手性恶唑类化合物的合成方法，可用于发现以分子氧为末端氧化剂的对映选择性烯烃环氧化催化剂。此外，将寻求用于不对称烯丙基置换的手性吡啶配体的一般合成。该项目的教育重点是将合成有机化学的当前应用与基础物理有机化学的关系纳入课程。通过这个职业计划，有机和高分子化学项目支持犹他大学化学系的马修·西格曼博士的研究和教学努力。西格曼教授将致力于开发用于不对称合成的新型手性配体。将以系统的方式组装配体，以便进行优化并直接了解反应机理。这种类型的方法开发为制药和农业提供了机会。西格曼博士的教育活动将集中在改进有机化学课程上。

The focus of this research is to develop a general synthesis of chiral oxazolines, which can be applied to the discovery of enantioselective olefin epoxidation catalysts using molecular oxygen as a terminal oxidant. Further, a general synthesis of chiral pyridine ligands for application to an asymmetric allylic displacement will be sought. The educational focus of the project is to incorporate, into the curriculum, the relationship of current applications in synthetic organic chemistry to the fundamentals physical organic chemistry.With this CAREER proposal, the Organic and Macromolecular Chemistry Program is supporting the research and teaching efforts of Dr. Matthew Sigman of the Department of Chemistry at the University of Utah. Professor Sigman will focus his work on developing new chiral ligands for applications in asymmetric synthesis. The ligands will be assembled in a systematic manner in order to allow for optimization and direct insight into reaction mechanisms. This type of methodology development presents opportunities for the pharmaceutical and agricultural industries. Dr. Sigman's educational activities will be focused on improving the organic chemistry curriculum.