Developing Asymmetric Catalysts Using Modular Ligands

该项目将继续致力于开发用于不对称催化的新配体。研究将集中在最近发现的恶唑啉衍生配体在活化卤化物对羰基化合物的对映选择性加成中的应用。此外，将利用所研究的配体的模块化来探索配体设计的潜在控制因素，最终目标是在催化剂设计中具有更强的预测能力。通过这个奖项，有机和大分子化学项目支持了犹他大学化学系马修·s·西格曼教授的研究。西格曼教授的研究重点是开发新的模块化手性配体，这将有助于手性构建块的快速合成。这种构建模块将对制药和农业行业的合成产生直接影响。

This project will continue work on the development of new ligands for applications in asymmetric catalysis. Studies will be focused on the application of recently discovered oxazoline derived ligands in enantioselective addition of activated halides to carbonyl compounds. Additionally, the underlying controlling elements of ligand design will be explored using the modularity of the ligands investigated with the ultimate goal of more predictive power in catalyst design. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Matthew S. Sigman of the Department of Chemistry at the University of Utah. Professor Sigman's research focuses on the development of new, modular chiral ligands that will contribute to the rapid synthesis of chiral building blocks. Such building blocks will have an immediate impact on synthesis in the pharmaceutical and agricultural industries.