Developing Asymmetric Catalysts Using Modular Ligands

使用模块化配体开发不对称催化剂

• 批准号: 0749506
• 负责人: Matthew Sigman
• 金额: $ 38.1万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-15 至 2012-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0749506&HistoricalAwards=false
• 关键词: Developing; Asymmetric; Catalysts; Using; Modular

This project will continue work on the development of new ligands for applications in asymmetric catalysis. Studies will be focused on the application of recently discovered oxazoline derived ligands in enantioselective addition of activated halides to carbonyl compounds. Additionally, the underlying controlling elements of ligand design will be explored using the modularity of the ligands investigated with the ultimate goal of more predictive power in catalyst design. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Matthew S. Sigman of the Department of Chemistry at the University of Utah. Professor Sigman's research focuses on the development of new, modular chiral ligands that will contribute to the rapid synthesis of chiral building blocks. Such building blocks will have an immediate impact on synthesis in the pharmaceutical and agricultural industries.

本计画将继续开发新的配体应用于不对称催化。 研究的重点是最近发现的恶唑啉衍生配体在活化卤化物对羰基化合物的不对称加成反应中的应用。 此外，配体设计的基本控制元素将探索使用模块化的配体研究与催化剂设计的预测能力的最终目标。 有了这个奖项，有机和高分子化学计划是支持教授马修S。犹他州大学化学系的西格曼说。 Sigman教授的研究重点是开发新的模块化手性配体，这将有助于快速合成手性结构单元。 这些基础材料将对制药和农业工业的合成产生直接影响。