CAREER: In Vivo Quantification of Tissue Deformation and Growth from Medical Image Data

职业：根据医学图像数据对组织变形和生长进行体内量化

• 批准号: 0134503
• 负责人: Jeffrey Weiss
• 金额: $ 37.43万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0134503&HistoricalAwards=false
• 关键词: CAREER; Vivo; Quantification; Tissue; Deformation

0134503WeissUnder this CAREER Award, methods from theoretical and computational mechanics will be combined with pattern theory to directly incorporate medical image data into the analysis of deforming biological tissues. Results will provide new finite-element based tools that use image data to track three-dimensional kinematics and nonlinear strain in deforming tissues and to register anatomical structures appearing in image data sets. Two applications would be targeted: in vivo measurement of strains in the beating human heart and in situ measurement of strains in ligaments. The techniques and resulting software, which will be made available to the public, are expected to be applicable in numerous other areas including geophysics, manufacturing engineering design, biology and computational medicine. The educational component focuses on three areas: bioengineering outreach to Utah high school students through a summer institute; developing an integrated biomechanics curriculum built around three core courses, and training undergraduate and graduate students in conjunction with research objectives.

0134503 Weiss在此职业奖下，理论和计算力学的方法将与模式理论相结合，直接将医学图像数据纳入变形生物组织的分析中。 结果将提供新的有限元为基础的工具，使用图像数据来跟踪三维运动学和变形组织中的非线性应变，并注册出现在图像数据集中的解剖结构。 两个应用程序将有针对性的：在跳动的人类心脏的应变在体内测量和韧带的应变在原位测量。 这些技术和由此产生的软件将向公众提供，预计将适用于许多其他领域，包括生物物理学，制造工程设计，生物学和计算医学。 教育部分侧重于三个领域：生物工程推广到犹他州高中学生通过暑期研究所;开发围绕三个核心课程建立的综合生物力学课程，并结合研究目标培训本科生和研究生。