CAREER: Design and Synthesis of Artificial Light-Gated Transmembrane Ion Channels

职业：人工光控跨膜离子通道的设计与合成

• 批准号: 0134792
• 负责人: Mary Gin
• 金额: $ 50万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0134792&HistoricalAwards=false
• 关键词: CAREER; Design; Synthesis; Artificial; Light

The Advanced Materials Program in the Division of Chemistry makes this Career award to University of Illinois Urbana-Champaign to study light-gated synthetic ion channels to control transmembrane currents. With this award, Professor Mary Gin will synthesize cyclodextrin-based channel scaffolds after regiospecific modifications. Modified cyclodextrins with a trapped pH sensitive dye will be embedded in homogenous lipid vesicles of approximately 25nm diameter. Ion transport activities of these lipid vesicles will be determined by measuring the fluorescence intensity changes in the dye. The planned studies are expected to result in the development of sensors; time released drugs and improved water purification systems. The educational component of the award is to assist students in Elementary Organic Chemistry courses, and to provide graduate and undergraduate students with hand-on experience in organic synthesis and modification of bioderived materials. Light-activated synthetic ion channels will be prepared from regiospecific-modified cyclodextrins and embedded in homogenous lipid vesicles with uniform diameter. Changes in fluorescence intensity of a pH sensitive dye trapped in these modified cyclodextrins will be utilized to measure ion transport activities of these synthetic ion channels. Sensors, time released drugs and improved water purification systems would be some of the potential applications coming out of these studies. In addition, this Career award will increase assistance to students in Elementary Organic Chemistry courses, and will provide them with research opportunities in organic synthesis and chemical modifications of bioderived materials.

化学部的先进材料计划将此职业奖授予伊利诺伊大学厄巴纳-香槟分校，以研究光门控合成离子通道来控制跨膜电流。 有了这个奖项，玛丽金教授将合成环糊精为基础的通道支架后，区域特异性修改。 具有捕获的pH敏感染料的改性环糊精将包埋在直径约25 nm的均匀脂质囊泡中。 这些脂质囊泡的离子转运活性将通过测量染料中的荧光强度变化来确定。 计划中的研究预计将导致传感器的开发;时间释放药物和改进的水净化系统。 该奖项的教育部分是帮助学生在小学有机化学课程，并提供研究生和本科生在有机合成和生物衍生材料的改性的实践经验。 光激活的合成离子通道将由区域特异性修饰的环糊精制备，并嵌入具有均匀直径的均匀脂质囊泡中。 捕获在这些改性环糊精中的pH敏感染料的荧光强度的变化将用于测量这些合成离子通道的离子转运活性。 传感器、定时释放药物和改进的水净化系统将是这些研究的一些潜在应用。 此外，该职业奖将增加对小学有机化学课程学生的帮助，并为他们提供有机合成和生物衍生材料化学修饰的研究机会。