PECASE: The Utilization of Complex Molecule Synthesis to Drive the Development of New Reaction Methods that Promote New Directions in Synthesis. A 'Teufelskreis' of Opportunity.

提案题目：PECASE：利用复杂分子合成推动新反应方法的发展，促进合成的新方向。机遇号的“Teufelskreis”。本研究的重点是在复杂分子合成的背景下开发新的合成方法。将开展钯催化氧化[4+2]环加成反应和串联Bamford-Stevens/Claisen重排的项目，并开发一种简洁、立体选择性的降糖二萜-糖苷的途径。在教育领域，正在编制有关合成和药物化学的课程，并开展外联活动，使学生能够与更广泛的当地社区进行互动。有了PECASE奖，有机和大分子化学项目支持加州理工学院化学和化学工程系的Brian Stoltz博士的研究和教育工作。Stoltz教授的研究重点是在天然产物全合成的框架内开发新的合成方法。说明性靶分子沙乌丁具有制药工业感兴趣的有趣的生物学特性。教育活动将强调与当地初中和高中的联系，并将侧重于本科和研究生一级的课程发展。该项目最初是作为职业奖资助的，并于2004年5月转换为工程师和科学家的总统早期职业奖（PECASE）奖。

Proposal Title: PECASE: The Utilization of Complex Molecule Synthesis to Drive the Development of New Reaction Methods that Promote New Directions in Synthesis. A 'Teufelskreis' of Opportunity.Institution: California Institute of TechnologyThe focus of this research is to develop new synthetic methodology in the context of complex molecule synthesis. Projects involving palladium-catalyzed oxidative [4+2] cycloaddition reactions and tandem Bamford-Stevens/Claisen rearrangements will be carried out and a concise, stereoselective route to the hypoglycemogenic diterpenoid, saudin will be developed. In the educational realm, courses on synthesis and pharmaceutical chemistry are being developed and outreach activities enabling students to interact with the broader local community are in place.With this PECASE award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Brian Stoltz of the Department of Chemistry and Chemical Engineering at the California Institute of Technology. Professor Stoltz will focus his research on the development of new synthetic methodology within the framework of natural product total synthesis. The illustrative target molecule, saudin, has interesting biological properties of interest to the pharmaceutical industry. The education activities will stress outreach to local middle schools and high schools and will also focus on course development at the undergraduate and graduate level.This project was originally funded as a CAREER award, and was converted to a Presidential Early Career Award for Engineers and Scientists (PECASE) award in May 2004.