Synthesis, Mechanistic Investigations, and Applications of Transition Metal Enolates for Asymmetric Synthesis

过渡金属烯醇化物的合成、机理研究及其在不对称合成中的应用

• 批准号: 1265591
• 负责人: Brian Stoltz
• 金额: $ 42万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1265591&HistoricalAwards=false
• 关键词: Synthesis; Mechanistic; Investigations; Applications; Transition

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Brian M. Stoltz of the Division of Chemistry and Chemical Engineering at the California Institute of Technology will investigate the origins of high enantioselectivity in an important asymmetric catalytic alkylation reaction discovered in his laboratory, and apply the knowledge gained toward the development of a broad platform for enantioselective transition metal enolate functionalization chemistry. The work described could provide unprecedented access to simple chemical building-blocks containing stereogenic centers, and could be widely adopted by synthetic chemists in both academia and industry. This unique collection of tools could enable chemists to push beyond the state-of-the-art in applying such technologies to compounds and substances that are beyond the scope of the current methods. In addition to the on-site, laboratory science described in this grant, the science proposed herein will directly impact the education of scientists at the California Institute of Technology, while the skill set and expertise they gain will broadly impact society-at-large as they too move on to productive careers in academia, industry, and government. Finally, ongoing teaching and outreach efforts with young students (K-6) will impact the lives and decisions of the next generation of students.

本研究由化学系化学合成项目资助，Brian M.加州理工学院化学与化学工程系的Stoltz将研究在他的实验室中发现的一个重要的不对称催化烷基化反应中的高对映选择性的起源，并将所获得的知识应用于对映选择性过渡金属烯醇化物官能化化学的广泛平台的开发。 所描述的工作可以提供前所未有的访问简单的化学积木含有立体中心，并可以广泛采用的合成化学家在学术界和工业界。 这种独特的工具集合可以使化学家在将这些技术应用于超出当前方法范围的化合物和物质方面超越最先进的技术。 除了现场，实验室科学在此补助金中所描述的，这里提出的科学将直接影响科学家在技术的加州研究所的教育，而他们获得的技能和专业知识将广泛影响社会在整个，因为他们也移动到学术界，工业界和政府的生产性职业生涯。 最后，与年轻学生（K-6）的持续教学和外联工作将影响下一代学生的生活和决定。