Informatics of Human and Monkey Brain Atlases

Jones，Edward G.0135396这个人脑项目将扩展我们以前在开发一个信息系统方面的努力，该系统可以存储，操作和检索由合作研究人员编制的大型数据集。该项目是围绕和设计来管理从高分辨率人类和猴子大脑图谱，分子和细胞映射研究，视网膜和丘脑细胞的形态测量和生理学，以及大脑连接的研究获得的数据。有一个负责监督、评估和传播的行政核心，以及4个将收集数据并在可视化和数据库中互动的研究项目。项目1将设计和整合信息方法，整合来自项目2-4的图形和非图形数据集，并使用外侧膝状体核作为模型，将开发用于构建和维护神经科学特定数据库的软件工具，用于将来自项目2- 4的各种信息集相互链接，以及用于从这些和其他神经科学数据集的信息的网络检索和交换。项目2将使用计算机辅助显微镜建立人类和猴子大脑的高分辨率数字地图集，扩展细胞结构以量化丘脑主要核团中的神经元群体（包括正常，精神分裂症和躁狂抑郁症的人类大脑），以及它们的受体和化学定义的细胞和传入纤维系统的概况。该项目包含了一个强大的可视化组件，由计算机科学家组成，他们在存储，操作和显示大型数据集方面具有专业知识。它将建立一个中央神经影像资料库，并与其他项目密切合作，开发用于操作、图形显示和浏览高分辨率组织学和神经化学脑图谱的软件工具，从外侧膝状体数据库开始，并使用互联网方法分发简化的影像。项目3将扩展视网膜细胞的数据库，其特征在于形态，化学，生理和连接，为外侧膝状体数据库提供模型和输入。项目4将开发一个猴子视觉丘脑和皮质-皮质连接的数据库，用于与外侧膝状体数据库集成，使用新开发的枕数据库作为模型。

Jones, Edward G.0135396This Human Brain Project will extend our previous efforts in developing an information system that can store, manipulate and retrieve large datasets compiled by the collaborating investigators. The project is built around and designed to manage data obtained from high resolution human and monkey brain atlases, molecular and cellular mapping studies, morphometry and physiology of retinal and thalamic cells, and studies of brain connections. There is an Administrative Core responsible for oversight, evaluation and dissemination and 4 Research Projects that will collect data and interact in visualization and databasing. Project 1 will design and integrate informational methods that integrate graphical and non-graphical datasets derived from Projects 2-4 and, using the lateral geniculate nucleus as a model, will develop software tools for building and maintaining neuroscience specific databases, for linking the diverse information sets derived from Projects 2--4 to one another, and for network retrieval and interchange of information from these and other neuroscience datasets. Project 2 will use computer assisted microscopy to build high resolution digital atlases of human and monkey brains, extending cytoarchitecture to quantify neuronal populations in the major nuclei of the thalamus (including in normal, schizophrenic and manic depressive human brains), and their profile of receptors and chemically defined cells and afferent fiber systems. This project incorporates a strong Visualization Component made up of computer scientists who have expertise in storage, manipulation and display of large datasets. It will populate a central NeuroImage Repository and, working in close conjunction with the other projects, will develop software tools for manipulating, graphically displaying and browsing the high resolution histological and neurochemical brain atlases, starting with the lateral geniculate database, and for distributing simplified images using Internet methodologies. Project 3 will expand a database of retinal cells characterized by morphology, chemistry, physiology and connectivity that provides the model for, and input to the lateral geniculate database. Project 4 will develop a database of monkey visual thalamo- and cortico-cortical connections for integration with the lateral geniculate database, using a newly developed pulvinar database as a model.