Informatics of Human and Monkey Brain Atlases

人类和猴子大脑图谱的信息学

• 批准号: 0135396
• 负责人: Stephen Koslow
• 金额: $ 1万
• 依托单位: National Institutes of Health Office on Neuroinformatics
• 依托单位国家: 美国
• 项目类别: Interagency Agreement
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0135396&HistoricalAwards=false
• 关键词: Informatics; Human; Monkey; Brain; Atlases

Jones, Edward G.0135396This Human Brain Project will extend our previous efforts in developing an information system that can store, manipulate and retrieve large datasets compiled by the collaborating investigators. The project is built around and designed to manage data obtained from high resolution human and monkey brain atlases, molecular and cellular mapping studies, morphometry and physiology of retinal and thalamic cells, and studies of brain connections. There is an Administrative Core responsible for oversight, evaluation and dissemination and 4 Research Projects that will collect data and interact in visualization and databasing. Project 1 will design and integrate informational methods that integrate graphical and non-graphical datasets derived from Projects 2-4 and, using the lateral geniculate nucleus as a model, will develop software tools for building and maintaining neuroscience specific databases, for linking the diverse information sets derived from Projects 2--4 to one another, and for network retrieval and interchange of information from these and other neuroscience datasets. Project 2 will use computer assisted microscopy to build high resolution digital atlases of human and monkey brains, extending cytoarchitecture to quantify neuronal populations in the major nuclei of the thalamus (including in normal, schizophrenic and manic depressive human brains), and their profile of receptors and chemically defined cells and afferent fiber systems. This project incorporates a strong Visualization Component made up of computer scientists who have expertise in storage, manipulation and display of large datasets. It will populate a central NeuroImage Repository and, working in close conjunction with the other projects, will develop software tools for manipulating, graphically displaying and browsing the high resolution histological and neurochemical brain atlases, starting with the lateral geniculate database, and for distributing simplified images using Internet methodologies. Project 3 will expand a database of retinal cells characterized by morphology, chemistry, physiology and connectivity that provides the model for, and input to the lateral geniculate database. Project 4 will develop a database of monkey visual thalamo- and cortico-cortical connections for integration with the lateral geniculate database, using a newly developed pulvinar database as a model.

这个人脑项目将扩展我们之前在开发信息系统方面的努力，该系统可以存储、操作和检索由合作研究人员汇编的大型数据集。该项目围绕和设计管理从高分辨率人和猴子脑图谱、分子和细胞图谱研究、视网膜和丘脑细胞的形态测量和生理学以及大脑连接研究中获得的数据。有一个行政核心负责监督、评价和传播，4个研究项目将收集数据，并在可视化和数据库方面进行互动。项目1将设计和整合从项目2-4得出的图形和非图形数据集的信息方法，并将以外侧膝状核为模型，开发软件工具，用于建立和维护专门针对神经科学的数据库，将项目2--4得出的各种信息集彼此联系起来，并从这些数据集和其他神经科学数据集进行网络检索和信息交流。项目2将使用计算机辅助显微镜建立人和猴子大脑的高分辨率数字图谱，扩展细胞结构以量化丘脑主要核团(包括正常、精神分裂症和躁狂抑郁的人脑)中的神经元种群，以及它们的受体、化学定义的细胞和传入纤维系统的概况。该项目包含一个强大的可视化组件，该组件由在存储、操作和显示大型数据集方面具有专业知识的计算机科学家组成。它将建立一个中央神经图像库，并将与其他项目密切合作，开发软件工具，从外侧膝状体数据库开始，操作、以图形显示和浏览高分辨率组织学和神经化学脑图谱，并使用互联网方法分发简化的图像。项目3将扩展一个以形态、化学、生理和连通性为特征的视网膜细胞数据库，该数据库为外侧膝状体数据库提供模型和输入。项目4将以新开发的枕骨数据库为模型，开发一个猴子视觉丘脑和皮质-皮质连接的数据库，以便与外侧膝状体数据库相结合。