Gas Phase Ion Chemistry: Conformation and Energetics of Biopolymers and Solvated Salt Crystals

在这个由化学部实验物理化学项目资助的项目中，鲍尔斯将对分子、簇、金属离子、肽、寡核苷酸和其他生物分子的离子迁移率进行研究。具体来说，将研究盐晶体溶剂化的能量学和机理，以及多肽/蛋白质和DNA/RNA寡核苷酸的构象。将研究它们的折叠、水化和与金属离子的相互作用的能量学。这些系统将在气相中进行研究，以避免由于溶剂效应而引起的并发症。本研究针对离子和生物分子在气相中迁移的基本问题。这些研究的结果将与理论建模相关联。研究生和本科生以及博士后研究助理将参与本研究。他们将接受当代物理化学前沿领域之一的培训，从而为进一步研究或在工业、学术界或政府实验室就业做好准备。

In this project funded by the Experimental Physical Chemistry Program of the Chemistry Division, Bowers will conduct research on the ion mobilities of molecules, clusters, metal ions, peptides, oligonucleotides, and other biomolecules. Specifically, work will be done on the energetics and mechanism of solvation of salt crystals, as well as on the conformations of polypeptides/proteins and DNA/RNA oligonucleotides. The energetics associated with their folding, hydration and interaction with metal ions will be investigated. These systems will be studied in the gas phase in order to avoid complications due to a solvent effect.This research attacks fundamental problems on the mobilities of ions and biomolecules in the gas phase. The results of these studies will be correlated with theoretical modeling. Graduate and undergraduate students as well as postdoctoral research associates will participate in this research. They will receive training in one of the forefront areas of contemporary physical chemistry and be thus prepared for advanced studies, or employment in industry, academia, or government laboratories.