NIRT: Enhancing the Properties of Nanoscale Electrospun Polymer Fibers thru Chemical Architecture, Surface Texturing Optimization Processing Protocols

NIRT：通过化学结构、表面纹理优化加工方案增强纳米级静电纺聚合物纤维的性能

• 批准号: 0210223
• 负责人: John Rabolt
• 金额: $ 108.75万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0210223&HistoricalAwards=false
• 关键词: NIRT; Enhancing; Properties; Nanoscale; Electrospun

This Nanoscale Interdisciplinary Team (NIRT), co-funded by the Divisions of Materials Research (DMR), Chemical and Transport Systems (CTS) and Design, Manufacturing and Industrial Innovation (DMII) will use genetically directed synthetic methods to permit exact control of the placement (at intervals of .6 nm, 1.0 nm, and/or 1.6 nm) of reactive chemical groups along a polypeptide backbone. These reactive groups will be both biologically active and electroactive providing novel materials for processing into fibers via electrospinning techniques. The fiber morphology, which will be varied by a judicious choice of processing conditions, will be characterized by electron microscopy, small angle neutron scattering and Raman spectroscopy. Mechanical properties of individual fibers will be evaluated using MEMS and NEMS devices while the biological activity of the electrospun fiber mats will be investigated by cell incubation studies.%%%The results of these investigations will provide molecular design rules for future biomaterial constructs and will lead to a new generation of tissue scaffold materials for wound repair. The hybrid bio-electronic materials that result will address some of the lifetime and brightness issues for next generation flat panel computer displays that are critical for future industrial manufacturing. The integration of this research and education through externship experiences at DuPont and the development of new courses on nanomaterials design and processing will provide knowledge and an experience base that will equip students with the work-force ready skills critically needed by industry.***

这个纳米级跨学科团队(NIRT)由材料研究(DMR)、化学和运输系统(CTS)以及设计、制造和工业创新(DMII)部门共同资助，将使用遗传指导的合成方法来精确控制活性化学基团沿多肽主干的放置(间隔为0.6 nm、1.0 nm和/或1.6 nm)。这些反应基团将具有生物活性和电活性，为通过静电纺丝技术加工成纤维提供了新的材料。电子显微镜、小角中子散射和拉曼光谱将对纤维形态进行表征，通过合理选择工艺条件可以改变纤维的形态。单个纤维的机械性能将使用MEMS和NEMS设备进行评估，而电纺纤维垫的生物活性将通过细胞培养研究进行研究。%这些研究结果将为未来的生物材料构建提供分子设计规则，并将导致用于伤口修复的新一代组织支架材料。由此产生的混合生物电子材料将解决下一代平板电脑显示器的一些寿命和亮度问题，这些问题对未来的工业制造至关重要。通过在杜邦的外部实习经验将这项研究和教育相结合，以及开发关于纳米材料设计和加工的新课程，将提供知识和经验基础，使学生掌握行业关键需要的劳动力准备技能。*