Acquisition of Supercritical Fluid Extraction and Countercurrent Chromatography Equipment for the Development of a "Green" Natural Products Isolation Laboratory

购置超临界流体萃取和逆流色谱设备，建设“绿色”天然产物分离实验室

• 批准号: 0215927
• 负责人: Craig Dodson
• 金额: $ 7.77万
• 依托单位: Colorado Mesa University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0215927&HistoricalAwards=false
• 关键词: Acquisition; Supercritical; Fluid; Extraction; Countercurrent

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Mesa State College will acquire preparative scale supercritical fluid (SCF) extraction equipment, preparative scale centrifugal countercurrent chromatography (CCC) equipment with UV detector, and accessories . This equipment will enhance research in a number of areas: a) plant secondary metabolites as mediators of trophic interactions in a tropical forest community; b) phytochemical investigation of cryptobiotic crusts and their alleged allelopathic interaction with non-native grasses; c) phytochemistry of neotropical piper species related to piper cenocladum and their role in defense against attine ant species; d) caterpillars of the Costa Rican rain forest; e) chemical mediation of trophic cascades in alfalfa and implications for biological control; and f) development of methodologies utilizing supercritical CO2 as a reaction solvent. The green approach to natural products isolation that will be developed with this equipment is timely and will benefit students in their future employment. In addition, these techniques could be of great value to scientists in the developing nations of Latin America whose immense biodiversity represents a wealth of undiscovered natural products of enormous potential. Therefore, scientists from Latin America who would otherwise not have access to SCF and CCC equipment will collaborate with the PI.

有了这项来自主要研究仪器（MRI）计划的奖项，梅萨州立学院化学系将获得制备规模的超临界流体（SCF）萃取设备，制备规模的离心逆流色谱（CCC）设备与紫外检测器和配件。这一设备将加强若干领域的研究：（a）植物次级代谢物作为热带森林群落营养相互作用的媒介物;（B）对隐生结皮及其与非本地草的所谓化感作用进行植物化学调查;（c）与新枝黄花胡椒有关的新热带地区胡椒物种的植物化学及其在抵御蚂蚁物种方面的作用; d）哥斯达黎加雨林的毛虫; e）苜蓿营养级联的化学介导和对生物控制的影响;和f）利用超临界CO2作为反应溶剂的方法学的发展。 该设备将开发的天然产物分离的绿色方法是及时的，将使学生在未来的就业中受益。 此外，这些技术可能对拉丁美洲发展中国家的科学家有很大的价值，因为这些国家的生物多样性丰富，蕴藏着大量潜力巨大的未被发现的自然产品。 因此，来自拉丁美洲的科学家将与主要研究者合作，否则他们将无法使用SCF和CCC设备。