Acquisition of a CCD X-ray Diffractometer for Chemical Crystallography Research and Education

购买 CCD X 射线衍射仪用于化学晶体学研究和教育

• 批准号: 0215950
• 负责人: R. Marshall Wilson
• 金额: $ 21.6万
• 依托单位: University of Cincinnati Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0215950&HistoricalAwards=false
• 关键词: Acquisition; CCD; ray; Diffractometer; Chemical

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at the University of Cincinnati will acquire an X-ray diffractometer with CCD detector for small molecule diffractometry. This equipment will enhance research in a number of areas including the following: a) the study of reactive intermediates in crystals; b) design of novel complexes as photodynamic therapeutic agents in the treatment of cancers; c) the study of unusual covalent and hydrogen-bonded geometries of promising catalysts and composite structures; d) the study of host-guest chemistry and molecular recognition; e) investigations on polymorphism and its role in drug interaction and design; and f) the design of supramolecular solids that can function as molecular machines, magnets and coordination polymers .The X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of the molecule relative to the neighboring molecules. These studies will have an impact in a number of areas, including the preparation of more efficient catalysts, drug development, and materials sciences.

在重大研究仪器 (MRI) 计划的支持下，辛辛那提大学化学系将购买一台带有 CCD 探测器的 X 射线衍射仪，用于小分子衍射分析。该设备将加强许多领域的研究，包括：a）晶体中反应性中间体的研究； b) 设计新型复合物作为治疗癌症的光动力治疗剂； c）研究有前途的催化剂和复合结构的不寻常的共价和氢键几何形状； d) 主客体化学和分子识别的研究； e) 研究多态性及其在药物相互作用和设计中的作用； f) 可用作分子机器、磁体和配位聚合物的超分子固体的设计。X射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于相邻分子的空间排列的准确信息。 这些研究将在许多领域产生影响，包括更高效催化剂的制备、药物开发和材料科学。