SBIR Phase II: New Elastomeric Microelectrodes for Improved Neuroprostheses

SBIR II 期：用于改进神经假体的新型弹性体微电极

• 批准号: 0216035
• 负责人: Francis Keohan
• 金额: $ 50万
• 依托单位: Cape Cod Research, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-10-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0216035&HistoricalAwards=false
• 关键词: SBIR; Phase; II; New; Elastomeric

This Small Business Innovation Research Phase II project is to develop electrically conductive polymer-silicone composite materials for improving the performance of implantable neural prostheses. Prior Phase I study has demonstrated the feasibility of synthesizing electrically conductive polymer nanocomposites with mechanical properties of silicone elastomers. Polymer-based prototype electrical devices were found to be stable toward simulated physiological conditions and cyclic current pulsing. The Phase II program will extend the benefits of these systems to the fabrication of more complex devices such as multi-poled cuff electrodes for chronic peripheral nerve stimulation and recording. An expanded test plan would include development of advanced device fabrication methods and extensive testing of the prototype neural prostheses for electrical response, tissue compatibility, and durability in chronic implantation applications. The optimized elastomeric electrodes will be characterized for biocompatibility, stability and electrical properties. Methodology will be developed for fabricating prosthetic electrodes for extensive in vitro pulsing studies and acute animal testing. Finally, test protocols for the new electrode products will be established in an effort to obtain FDA approval. The commercial applications of this project will be in the area of biomedical devices and systems that serve the needs of disabled individuals following stroke or spinal cord injury.

该小企业创新研究第二期项目旨在开发导电聚合物-有机硅复合材料，以提高植入式神经假体的性能。先前的第一阶段研究已经证明了合成具有有机硅弹性体机械性能的导电聚合物纳米复合材料的可行性。人们发现基于聚合物的原型电气设备对于模拟生理条件和循环电流脉冲是稳定的。第二阶段计划将把这些系统的优势扩展到更复杂的设备的制造，例如用于慢性周围神经刺激和记录的多极袖带电极。扩展的测试计划将包括开发先进的设备制造方法以及对原型神经假体进行广泛的测试，以测试其在长期植入应用中的电响应、组织相容性和耐用性。优化的弹性体电极将具有生物相容性、稳定性和电学特性。将开发用于制造假体电极的方法，用于广泛的体外脉冲研究和急性动物测试。最后，将制定新电极产品的测试方案，争取获得 FDA 批准。 该项目的商业应用将在生物医学设备和系统领域，以满足中风或脊髓损伤后残疾人的需求。