SBIR Phase II: A Novel Technique for Polymer Encapsulation of Nanopowders

这个小企业创新研究（SBIR）第二阶段项目将专注于开发聚合物涂层的超顺磁性纳米珠，用于分离生物分子，即细胞和核酸。超顺磁性沿着“纳米”尺寸的颗粒提供了低剩磁、低场下的磁化和每单位体积更大的活性表面积。采用专有的微波等离子体合成技术来减少这些纳米球，并在第一阶段确定了该技术的可行性。工艺规模扩大和广泛的细胞/DNA分离试验将是第II阶段项目的主要研发目标。工业合作伙伴将评估生产的珠子，以评估参数，这些参数对于将技术转化为立即有用的产品至关重要。聚合物包覆的纳米球的商业潜力可用于各种分离模块。该技术还可以扩展到水中病原体的分离和检测。

This Small Business Innovation Research (SBIR) Phase II project will focus on developing polymer coated superparamagnetic nanobeads for isolation of biomolecules; namely cells and nucleic acids. The superparamagnetic nature along with the "nano" size of the particles offers low remnant magnetism, magnetization at low fields, and larger active surface area per unit volume. A proprietary microwave plasma synthesis technique was adopted to reduce these nanospheres and the feasibility of the technique was established during Phase I. Process scale up and extensive cell/DNA isolation testing will be the main R&D objectives for the Phase II project. Industrial partners will evaluate beads produced to evaluate parameters, which are critical for transitioning the technology to an immediate useful product. The commercial potential of polymer coated nanospheres can be used in various separation modules. This technology could also be extended to isolation and detection of pathogens in water.