Conference on Frontiers of NMR in Molecular Biology - VIII to be held in Taos, New Mexico at the Taos Covention Center, February 4-10, 2003

分子生物学核磁共振前沿会议 - VIII 将于 2003 年 2 月 4-10 日在新墨西哥州陶斯的陶斯会议中心举行

• 批准号: 0228138
• 负责人: James Prestegard
• 金额: $ 1.2万
• 依托单位: Keystone Symposia on Molecular and Cellular Biology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0228138&HistoricalAwards=false
• 关键词: Conference; Frontiers; NMR; Molecular; Biology

This project supports attendance of students at the Keystone Symposium on the Frontiers of Nuclear Magnetic Resonance (NMR) in Molecular Biology, which will be held at Taos, New Mexico from February 4-10, 2003. The timely topic of this conference reflects the fact that NMR has continued to evolve to meet new challenges of molecular biology and genomics. Already the challenge of providing structures of proteins on a genomic scale has produced new NMR approaches to efficient structure determination. The prospect of having more targets to implement in biotechnology applications has spawned new means of screening for small-molecule and macromolecule interactions. The realization that biological function often involves the interplay of groups of macromolecules in a dynamic setting has led to new methods for monitoring interactions and motion in large macromolecular complexes. With new approaches and new realizations come additional challenges. Large volumes of data and new types of data demand innovative approaches to analysis, assemblies of interacting macromolecules means working with ever-larger structures, and new sources of data on protein dynamics require new connections to mechanistic models. New technological advances needed to work with larger systems often come from combining solids NMR with solution NMR approaches. Computational biology is well poised to organize diverse types of data, generate molecular models, and turn them into predictive tools. The ultimate challenge for the meeting will be to stimulate discussion among scientists coming from these diverse fields. The meeting will highlight new approaches to the challenges defined above and provide a forum for discussion among molecular biologists, NMR spectroscopists, and computational biologists. The program will be organized around problem areas and integrate talks by scientists having different perspectives on their solution. Scheduled breaks between formal presentation sessions are ideal for simulating discussion among participants, and promoting contact between students and established leaders in these diverse fields. The interdisciplinary character of the meeting, as described above, will broaden its potential impact. The meeting will also have a distinct educational component by its support for the attendance of graduate students and postdoctoral associates. Discussion of more practical aspects of the field will be promoted by the organization of afternoon workshops having a less formal structure. These will enhance opportunities for interaction of students with established scientist working in the area.

本项目支持学生参加将于2003年2月4日至10日在新墨西哥州陶斯举行的分子生物学核磁共振前沿专题讨论会。这次会议的及时主题反映了核磁共振继续发展以满足分子生物学和基因组学的新挑战的事实。在基因组尺度上提供蛋白质结构的挑战已经产生了新的核磁共振方法来有效地确定结构。在生物技术应用中有更多靶点的前景催生了筛选小分子和大分子相互作用的新方法。认识到生物功能通常涉及大分子群在动态环境中的相互作用，导致了监测大型大分子复合物相互作用和运动的新方法。新的方法和新的实现带来了更多的挑战。大量的数据和新类型的数据需要创新的分析方法，相互作用的大分子的组装意味着要处理更大的结构，蛋白质动力学的新数据源需要与机制模型建立新的联系。大型系统所需的新技术进步通常来自固体核磁共振与溶液核磁共振方法的结合。计算生物学可以很好地组织不同类型的数据，生成分子模型，并将其转化为预测工具。这次会议的最终挑战将是激发来自这些不同领域的科学家之间的讨论。会议将重点介绍应对上述挑战的新方法，并为分子生物学家、核磁共振波谱学家和计算生物学家提供一个讨论论坛。该项目将围绕问题领域进行组织，并整合从不同角度解决问题的科学家的谈话。在正式演示会议之间安排休息时间是模拟参与者之间讨论的理想选择，并促进学生与这些不同领域的知名领导者之间的联系。如上所述，会议的跨学科性质将扩大其潜在影响。会议还将有一个独特的教育组成部分，支持研究生和博士后助理的出席。组织结构不太正式的下午讲习班将促进对该领域更实际方面的讨论。这将增加学生与在该领域工作的知名科学家互动的机会。