Purchase of a Multi-User MALDI-TOF Mass Spectrometer

购买多用户 MALDI-TOF 质谱仪

• 批准号: 0234796
• 负责人: Douglas Neckers
• 金额: $ 12.44万
• 依托单位: Bowling Green State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0234796&HistoricalAwards=false
• 关键词: Purchase; Multi; User; MALDI; TOF

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at Bowling Green State University will acquire a Matrix-assisted Laser Desorption Ionization - Time of Flight (MALDI-TOF) Mass Spectrometer. This instrument will be used in a wide variety of research projects, including a) investigations on novel metal-organic chromophores and materials; b) studies of de novo designed proteins for use in electron transfer and DNA damage; c) studies of supramolecular materials as anion sensors; and d) investigations on self-assembled RNA motifs. Matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry is the technique of choice for obtaining accurate molecular weights on molecules up to and over 300,000 daltons, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique in studies involving biomolecules. At Bowling Green, this instrument will therefore also be used in the undergraduate Biochemistry laboratory for protein analysis.

在化学研究仪器和设施（CRIF）项目的支持下，鲍灵格林州立大学化学系将获得一台矩阵辅助激光解吸电离飞行时间（MALDI-TOF）质谱仪。该仪器将用于各种各样的研究项目，包括a)新型金属有机发色团和材料的研究；b)研究用于电子转移和DNA损伤的从头设计的蛋白质；C)超分子材料作为阴离子传感器的研究；d)自组装RNA基序的研究。矩阵辅助激光解吸电离（MALDI）飞行时间（TOF）质谱法是获得精确分子质量的技术选择高达和超过300,000道尔顿，具有极高的灵敏度。因此，使用MALDI-TOF质谱仪已成为涉及生物分子研究的标准技术。因此，在鲍灵格林，该仪器也将在本科生物化学实验室用于蛋白质分析。