CAREER: The Assessment of Extinction Risk from Deleterious Mutation, Habitat Fragmentation, and Environmental Change
职业:有害突变、栖息地破碎化和环境变化带来的灭绝风险评估
基本信息
- 批准号:0238354
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-04-01 至 2009-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Extinction is controlled by habitat destruction, disease, harvest, birth rate and the genetic health of a population, among other factors. This study uses high-performance supercomputing to realistically simulate the forces on natural populations to understand which types of wildlife are most likely to face extinction. To ensure that the project produces new knowledge of practical importance on the causes of extinction, and new computational tools that will be useful to managers of natural populations, the project will work closely with Native American and Federal salmon biologists in the Pacific Northwest and population biologists in Europe.There is wide recognition that life on Earth is undergoing a sixth major extinction event caused by human generated forces. Preventing extinction has been a high priority of people for many years. This project will help conserve natural systems by discovering new scientific knowledge on the causes of extinction. Most previous theoretical work on extinction focused on only one or two extinction forces at a time, for reasons of mathematical tractability. However, the multiplicity of forces controlling the fate of natural populations are inexorably intertwined,operating simultaneously and synergistically. This innovative project seeks to understand how extinction is governed by the interplay of these forces by using mechanistic computer models that capture essential levels of environmental and biological complexity.
灭绝是由栖息地破坏,疾病,收获,出生率和人口的遗传健康等因素控制的。这项研究使用高性能超级计算来逼真地模拟自然种群的力量,以了解哪些类型的野生动物最有可能面临灭绝。为了确保该项目产生关于灭绝原因的具有实际重要性的新知识,以及对自然种群管理人员有用的新计算工具,该项目将与太平洋西北部的美洲土著和联邦鲑鱼生物学家以及欧洲的种群生物学家密切合作,人们广泛认识到,地球上的生命正在经历由人类力量造成的第六次重大灭绝事件。多年来,防止灭绝一直是人们的高度优先事项。该项目将通过发现有关灭绝原因的新科学知识来帮助保护自然系统。由于数学上的易处理性,大多数以前关于灭绝的理论工作一次只关注一种或两种灭绝力。然而,控制自然种群命运的多种力量不可阻挡地交织在一起,同时协同运作。这个创新的项目旨在了解灭绝是如何通过使用机械计算机模型,捕捉环境和生物复杂性的基本水平,这些力量的相互作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kevin Higgins其他文献
A multi-centre, participant-blinded, randomized, 3-year study to compare the efficacy of Virtual Surgical Planning (VSP) to Freehand Surgery (FHS) on bony union and quality of life outcomes for mandibular reconstruction with fibular and scapular free flaps: study protocol for a randomized phase II/III trial
- DOI:
10.1186/s12885-025-13505-5 - 发表时间:
2025-02-27 - 期刊:
- 影响因子:3.400
- 作者:
Khanh Linh Tran;Sena Turkdogan;Anat Bahat Dinur;Thomas D. Milner;Edward Wang;Anthony Nichols;Danielle MacNeil;Adrian Mendez;Jake Jervis-Bardy;John De Almeida;Christopher Yao;David Goldstein;Ralph Gilbert;Antoine Eskander;Kevin Higgins;Danny Enepekides;Michael Gupta;Han Zhang;Michael Au;Sally Nguyen;Sidney Fels;Antony Hodgson;Penelope Brasher;Craig Mitton;Farahna Sabiq;Charles Fisher;David Yang;Angela Wong;Cathie Garnis;Catherine Poh;J. Scott Durham;Eitan Prisman - 通讯作者:
Eitan Prisman
Radiation vs. trans-oral surgery for treatment de-escalation in HPV-related oropharyngeal cancers: Primary analysis of the ORATOR2 randomized trial
放疗与经口手术用于人乳头瘤病毒(HPV)相关口咽癌的治疗降阶梯:ORATOR2随机试验的初步分析
- DOI:
10.1016/j.ejca.2025.115343 - 发表时间:
2025-05-02 - 期刊:
- 影响因子:7.100
- 作者:
David A. Palma;Eitan Prisman;Eric Berthelet;Eric Tran;Sarah Hamilton;Jonn Wu;Antoine Eskander;Kevin Higgins;Irene Karam;Ian Poon;Zain Husain;Danny Enepekides;Michael Hier;Keith Richardson;Alex Mlynarek;Stephanie Johnson-Obaseki;Marc Gaudet;Andrew Bayley;Samuel Dowthwaite;James E. Jackson;Anthony C. Nichols - 通讯作者:
Anthony C. Nichols
Transient Absorption Microscopy, Instrumentation and Application to Amphotericin B
两性霉素 B 的瞬时吸收显微镜、仪器和应用
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
Kevin Higgins - 通讯作者:
Kevin Higgins
110 - Retrospective Application of the 2015 ATA Guidelines for Ultrasound Classification, Biopsy Indications and Follow up Imaging of Thyroid Nodules: Can improved reporting decrease testing?
- DOI:
10.1016/j.jcjd.2017.08.118 - 发表时间:
2017-10-01 - 期刊:
- 影响因子:
- 作者:
Manijeh Mohammadi;Carrie Betel;Kirsteen Burton;Kevin Higgins;Zeina Ghorab;Ilana Halperin - 通讯作者:
Ilana Halperin
3409: Radiotherapy vs. Trans-Oral Surgery for Treatment De-Escalation in HPV-Associated Oropharyngeal Squamous Cell Carcinoma: Primary Analysis of the ORATOR2 Trial
3409:放射疗法与跨口腔手术,用于与HPV相关的口咽鳞状细胞癌中的治疗降低:Otrator2试验的主要分析
- DOI:
10.1016/s0167-8140(24)03371-1 - 发表时间:
2024-05-01 - 期刊:
- 影响因子:5.300
- 作者:
David A. Palma;Eric Berthelet;Sarah Hamilton;Jonn Wu;Antoine Eskander;Kevin Higgins;Irene Karam;Michael Hier;Keith Richardson;Alex Mlynarek;Marc Gaudet;Andrew Bayley;Marcin Dzienis;Shamir Chandarana;Robyn Banerjee;Robert Hart;Jeffson Chung;Hien Le;Eric Winquist;Andrew Warner;Anthony C. Nichols - 通讯作者:
Anthony C. Nichols
Kevin Higgins的其他文献
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{{ truncateString('Kevin Higgins', 18)}}的其他基金
EAGER: The Joint Ecological and Genetic Dynamics of Metapopulation Extinction
EAGER:种群灭绝的联合生态和遗传动力学
- 批准号:
0951188 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Standard Grant
Postdoctoral Research Fellowship in Biosciences Related to the Environment for FY 1998
1998财年与环境相关的生物科学博士后研究奖学金
- 批准号:
9804267 - 财政年份:1998
- 资助金额:
-- - 项目类别:
Fellowship Award
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