CAREER: Dynamics of Polymer Collisions

摘要-0239012P。这个项目是对传输现象的教育和研究的一种综合方法，重点是聚合物动力学。研究部分侧重于对聚合物碰撞的基本了解。DNA将作为模型聚合物，直接观察聚合物与障碍物的碰撞动力学。除了添加聚合物外，一种制造动态障碍物的新方法将利用自组装磁性胶体。这将允许探索各种各样的碰撞动力学。除了DNA之外，还将开发随机模拟，其中考虑到障碍本身的微观结构和动力学。将开发多尺度模拟来同时模拟DNA-聚合物-胶体碰撞。这项工作将对芯片实验室设备中的DNA分离领域产生直接影响，在这些领域中，碰撞最终导致尺寸分离，并了解复杂液体的流变学，其中碰撞可能采取瞬时纠缠的形式。在开展该项目研究工作的同时，还将制定一项综合教育计划。本科生将参与微观研究项目，这些项目将产生模块，这些模块将用于加强PI教授的研究生课程。这些模块将强调运输现象的分子方面。将开发一门新的研究生课程，涵盖生物学、聚合物和工程学等主题。该协会最近推出的一个新的本科生动手实践工作坊将得到进一步发展。KIPP学院的科学教师(针对高危年级儿童)将得到指导，并为他们举办年度讲习班。

ABSTRACTCTS-0239012P. DOYLE, MITThis program is an integrated approach to education and research of transport phenomena with an emphasis on polymer dynamics. The research portion focuses on a fundamental understanding of polymer collisions. DNA will be used as a model polymer to directly observe the collision dynamics of polymers with obstacles. A novel approach to producing dynamic obstacles will make use of self- assembling magnetic colloids, in addition to added polymers. This will allow for a wide variety of collision dynamics to be explored. Stochastic simulations will be developed which take into account the microstructure and dynamics of the obstacles themselves, in addition to the DNA. Multiscale simulations will be developed for simultaneous simulation of DNA-polymer-colloidal collisions. This work will have direct impact on the fields of DNA separations in lab-on-chip devices where collisions ultimately lead to size separation and also understanding the rheology of complex liquids where collisions can take the form of transient entanglements. In parallel to the research portion of this project, an integrated education plan will be developed. Undergraduates will participate in micro research projects that will produce modules which will be used to enhance graduate courses taught by the PI. These modules will stress molecular aspects of transport phenomena. A new graduate course covering topics in biology, polymers and engineering will be developed. A new undergraduate Hands on ChE workshop recently introduced by the PI will be further developed. Science teachers from the KIPP Academy (for at-risk grade school children) will be mentored and an annual workshop for them.