SBIR Phase II: Comprehensive Database Resource on Protein Localization

SBIR 第二阶段：蛋白质定位综合数据库资源

• 批准号: 0239206
• 负责人: David Rubin
• 金额: $ 49.94万
• 依托单位: Cognia Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0239206&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Comprehensive; Database

This Small Business Innovation Research (SBIR) Phase II Project proposes to develop the database and associated software to enable analysis of protein trafficking and localization. The system will be designed to enable drug discovery researchers to identify, elucidate, eliminate and design leads and targets, while facilitating the general training of researchers. During the Phase I work, proteins involved in trafficking and diseases related to mislocalization were identified, and a relational database to house information on protein trafficking was constructed. Curation interface applications were created to allow remote data entry, and graphical user interfaces designed to maximize the utility of the information. The objective of this Phase II Project is to exhaustively populate the database from the primary journal literature. Selection of proteins involved in protein trafficking will be guided by relevant human diseases and corresponding drug discovery efforts. The commercial application of this project is in the area of biological informatics. The potential users of the biological database to be developed in this project would include pharmaceutical and drug discovery companies.

该小型企业创新研究 (SBIR) 第二阶段项目建议开发数据库和相关软件，以实现蛋白质运输和本地化分析。该系统的设计目的是使药物发现研究人员能够识别、阐明、消除和设计先导化合物和靶点，同时促进研究人员的一般培训。在第一阶段的工作中，确定了参与贩运的蛋白质和与错误定位相关的疾病，并构建了一个存储蛋白质贩运信息的关系数据库。创建管理界面应用程序是为了允许远程数据输入，图形用户界面旨在最大限度地提高信息的效用。 该第二阶段项目的目标是从主要期刊文献中详尽地填充数据库。参与蛋白质运输的蛋白质的选择将以相关的人类疾病和相应的药物发现工作为指导。该项目的商业应用是在生物信息学领域。该项目中开发的生物数据库的潜在用户包括制药和药物发现公司。