SBIR Phase I: Comprehensive Database Resource on Protein Localization

SBIR 第一阶段：蛋白质定位综合数据库资源

• 批准号: 0128604
• 负责人: David Rubin
• 金额: $ 9.99万
• 依托单位: Cognia Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0128604&HistoricalAwards=false
• 关键词: SBIR; Phase; Comprehensive; Database; Resource

This Small Business Innovation Research (SBIR) Phase I project will enable the development of the first knowledge management system dedicated specifically to protein localization (ProLoc). Data generated from high-throughput genomic and proteomic experimentation and information published across the entire spectrum of cellular and molecular biology is proliferating at exponential rates. Moreover, current database systems remain incapable of handling the intricate network of relationships between proteins. ProLoc, a database system that integrates expert-curated information from published literature with primary data from a range of experimental methodologies, will begin to attack this problem by focusing on one discrete area of cell biology (protein localization). Researchers will be able to mine pathways and mechanisms, leading to disease elucidation and new therapies. Phase I will be used to create the framework for a functioning relational database, with representative entries for initial beta testing. This will provide an essential foundation for Phase II, when comprehensive content and ancillary tools will be added, creating a highly structured, sophisticated, and interactive relational database system. Once the daunting challenge of reflecting biological pathways into standard database formats has been met through the ProLoc database, the ProLoc structure can be extended to many other cell regulation pathways and processes.ProLoc will stand out as an extremely high quality specialized resource in the field of protein localization that will be a necessary part of any set of molecular biology benchtop databases and tools.

这个小型企业创新研究(SBIR)第一阶段项目将使第一个专门针对蛋白质本地化(ProLoc)的知识管理系统的开发成为可能。从高通量基因组和蛋白质组实验中产生的数据以及在整个细胞和分子生物学领域发表的信息正在以指数速度增长。此外，目前的数据库系统仍然无法处理蛋白质之间错综复杂的关系网络。ProLoc是一个数据库系统，它将来自已发表文献的专家精选的信息与来自一系列实验方法的原始数据相结合，将开始通过专注于细胞生物学的一个离散领域(蛋白质定位)来解决这个问题。研究人员将能够挖掘途径和机制，导致疾病阐明和新的治疗方法。第一阶段将用于创建运行关系数据库的框架，具有代表性的条目用于初始Beta测试。这将为第二阶段提供必要的基础，届时将增加全面的内容和辅助工具，创建一个高度结构化、复杂和互动的关系数据库系统。一旦通过ProLoc数据库解决了将生物学途径反映为标准数据库格式的艰巨挑战，ProLoc结构就可以扩展到许多其他细胞调节途径和过程。ProLoc将作为蛋白质定位领域的一种极高质量的专业资源脱颖而出，它将是任何一套分子生物学台式数据库和工具的必要组成部分。