CAREER: Biomolecule-Macromolecule Interactions at Surfaces and Interfaces

职业：表面和界面处的生物分子-大分子相互作用

• 批准号: 0239633
• 负责人: Alan Esker
• 金额: $ 51万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0239633&HistoricalAwards=false
• 关键词: CAREER; Biomolecule; Macromolecule; Interactions; Surfaces

Professor Alan Esker of Virginia Polytechnic Institute is supported by the Analytical and Surface Chemistry Program to study magnetic nanoparticles and their aggregation, adsorption, transport and viscoelastic properties in biomimetic lipid systems. Applied magnetic fields can alter fundamental lipid-nanoparticle interactions, which are particularly relevant for drug delivery and therapeutic applications. This CAREER award also supports the PI's goal of attracting students to macromolecular physical chemistry with innovative research experiences for undergraduates and research on enzyme kinetics as part of the physical chemistry course.Magnetic nanoparticles have attracted considerable attention for separations, biosensing, targeted delivery of therapeutic agents and magnetic resonance imaging contrast agents. Basic research into their interactions with membranes will ultimately lead to improvements in these applications.

弗吉尼亚理工学院的 Alan Esker 教授在分析和表面化学项目的支持下研究磁性纳米颗粒及其在仿生脂质系统中的聚集、吸附、运输和粘弹性特性。 施加的磁场可以改变基本的脂质-纳米颗粒相互作用，这与药物输送和治疗应用特别相关。 该职业奖还支持PI的目标，即通过本科生的创新研究经验以及作为物理化学课程一部分的酶动力学研究来吸引学生进入大分子物理化学。磁性纳米粒子在分离、生物传感、治疗剂和磁共振成像造影剂的靶向递送方面引起了相当大的关注。 对它们与膜相互作用的基础研究最终将导致这些应用的改进。